2.1.1.85: protein-histidine N-methyltransferase

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For detailed information about protein-histidine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

actin His73 nmethyltransferase, actin histidine methyltransferase, actin histidine-N3 methyltransferase, actin-specific histidine methyltransferase, actin-specific histidine N-methyltransferase, actin-specific methyltransferase, methyltransferase, protein (histidine), protein (actin) histidine MTase, protein methylase IV, S-adenosyl methionine:protein-histidine N-methyltransferase, SET domain protein 3, setd3

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.85 protein-histidine N-methyltransferase

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Results	in table
2	Activating Compound
1871	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
3	Crystallization (Commentary)
18	Disease/ Diagnostics
3	General Information
1	General Stability
8	Inhibitors
22	kcat/KM [mM/s]
22	KM Value [mM]
4	Localization
1	Metals/Ions
1	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
7	Organism
19	PDB ID
1	pH Optimum
1	pH Range
11	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
23	Substrates and Products (Substrate)
3	Subunits
20	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
22	Turnover Number [1/s]

General Information

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General Information on EC 2.1.1.85 - protein-histidine N-methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

2 entries

physiological function

Homo sapiens

Q86TU7

the enzyme plays important roles in hypoxic pulmonary hypertension, muscle differentiation, and carcinogenesis

756580

malfunction

Homo sapiens

Q86TU7

enzyme depletion impairs signal-induced contraction in primary uterine smooth muscle cells

757802

malfunction

Mus musculus

-

enzyme-deficient female mice have severely decreased litter sizes owing to primary maternal dystocia that is refractory to ecbolic induction agents

757802