2.1.1.85: protein-histidine N-methyltransferase
This is an abbreviated version!
For detailed information about protein-histidine N-methyltransferase, go to the full flat file.
Reaction
Synonyms
actin His73 nmethyltransferase, actin histidine methyltransferase, actin histidine-N3 methyltransferase, actin-specific histidine methyltransferase, actin-specific histidine N-methyltransferase, actin-specific methyltransferase, methyltransferase, protein (histidine), protein (actin) histidine MTase, protein methylase IV, S-adenosyl methionine:protein-histidine N-methyltransferase, SET domain protein 3, setd3
ECTree
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Engineering
Engineering on EC 2.1.1.85 - protein-histidine N-methyltransferase
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N255A
the mutant has increased lysine methylation activity and decreased histidine methylation activity compared to the wild type enzyme
N255V
the mutant has increased lysine methylation activity and decreased histidine methylation activity compared to the wild type enzyme
N256A
the mutant shows severely reduced activity compared to the wild type enzyme
N256D
the mutant shows severely reduced activity compared to the wild type enzyme
N256Q
the mutant shows about 50% activity compared to the wild type enzyme
N278A
the mutant shows severely reduced activity compared to the wild type enzyme
R215A
the mutant shows severely reduced activity compared to the wild type enzyme
R316A
the mutant shows severely reduced activity compared to the wild type enzyme
R75A
the mutant shows severely reduced activity compared to the wild type enzyme
Y313F
the mutant shows severely reduced activity compared to the wild type enzyme