2.1.1.85: protein-histidine N-methyltransferase

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For detailed information about protein-histidine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

actin His73 nmethyltransferase, actin histidine methyltransferase, actin histidine-N3 methyltransferase, actin-specific histidine methyltransferase, actin-specific histidine N-methyltransferase, actin-specific methyltransferase, methyltransferase, protein (histidine), protein (actin) histidine MTase, protein methylase IV, S-adenosyl methionine:protein-histidine N-methyltransferase, SET domain protein 3, setd3

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.85 protein-histidine N-methyltransferase

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Results	in table
2	Activating Compound
1871	AA Sequence
1	CAS Registry Number
4	Cloned(Commentary)
3	Crystallization (Commentary)
18	Disease/ Diagnostics
3	General Information
1	General Stability
8	Inhibitors
22	kcat/KM [mM/s]
22	KM Value [mM]
4	Localization
1	Metals/Ions
1	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
7	Organism
19	PDB ID
1	pH Optimum
1	pH Range
11	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
7	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
23	Substrates and Products (Substrate)
3	Subunits
20	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
2	Temperature Stability [°C]
22	Turnover Number [1/s]

Disease

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Disease on EC 2.1.1.85 - protein-histidine N-methyltransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinogenesis

SETD3 acts as a prognostic marker in breast cancer patients and modulates the viability and invasion of breast cancer cells.

32042016

Carcinoma

SETD3 acts as a prognostic marker in breast cancer patients and modulates the viability and invasion of breast cancer cells.

32042016

Dystocia

SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

30626964

Encephalitis, Viral

Enterovirus pathogenesis requires the host methyltransferase SETD3.

31527793

Myelitis

Enterovirus pathogenesis requires the host methyltransferase SETD3.

31527793

Neoplasms

A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells.

34469831

Neoplasms

[NSD3 suppresses LPS-triggered TNF-? production via promoting the dimethylation of histone H3K36 in macrophages].

30236198

Uterine Cervical Neoplasms

SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.

31235251

Virus Diseases

Enterovirus pathogenesis requires the host methyltransferase SETD3.

31527793

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