1.8.1.B1: thioredoxin glutathione reductase
This is an abbreviated version!
For detailed information about thioredoxin glutathione reductase, go to the full flat file.
Word Map on EC 1.8.1.B1
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1.8.1.B1
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schistosoma
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schistosomiasis
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worm
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mansoni
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praziquantel
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glutaredoxin
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selenocysteine
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antischistosomal
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gssg
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auranofin
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platyhelminth
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flatworm
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dtnb
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fluke
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sjtgr
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fasciola
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oxadiazole
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cysticerci
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hysteretic
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medicine
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taenia
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trematode
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echinococcus
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granulosus
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schistosomicidal
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crassiceps
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gigantica
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selenocysteine-containing
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furoxans
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analysis
- 1.8.1.B1
- schistosoma
- schistosomiasis
- worm
- mansoni
- praziquantel
- glutaredoxin
- selenocysteine
-
antischistosomal
- gssg
- auranofin
-
platyhelminth
- flatworm
- dtnb
- fluke
-
sjtgr
- fasciola
-
oxadiazole
- cysticerci
-
hysteretic
- medicine
-
taenia
-
trematode
-
echinococcus
- granulosus
-
schistosomicidal
- crassiceps
- gigantica
-
selenocysteine-containing
- furoxans
- analysis
Reaction
Synonyms
cTGR, DmTrxR, EgTGR, mTGR, SmTGR, TGR, TGRsec, thioredoxin glutathione reductase, thioredoxin-glutathione reductase, thioredoxin/glutathione reductase
ECTree
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Source Tissue
Source Tissue on EC 1.8.1.B1 - thioredoxin glutathione reductase
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thioredoxin glutathione reductase appears to be the major, if not the sole enzyme for these activities in adult worms, completely replacing thioredoxin reductase and glutathione reductase
additional information
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no expression in caecum, muscle, and parenchyma of juvenile nor in spine and muscle of adult
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TGR is regulated by both selenium availability and selenocysteine tRNA status. This regulation is more pronounced in liver, whereas in testes, the expression level is only slightly affected
much higher number of TGR transcripts in testis than in the rest of organs
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TGR is not detected in the testes of a 20-day-old mouse. It is highly expressed in 7-month-old mouse testes. The enzyme accumulates in testes after puberty. The protein is particularly abundant in elongating spermatids at the site of mitochondrial sheath formation but is absent in mature sperm
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TGR is regulated by both selenium availability and selenocysteine tRNA status. This regulation is more pronounced in liver, whereas in testes, the expression level is only slightly affected