1.8.1.B1: thioredoxin glutathione reductase
This is an abbreviated version!
For detailed information about thioredoxin glutathione reductase, go to the full flat file.
Word Map on EC 1.8.1.B1
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1.8.1.B1
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schistosoma
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schistosomiasis
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worm
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mansoni
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praziquantel
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glutaredoxin
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selenocysteine
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antischistosomal
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gssg
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auranofin
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platyhelminth
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flatworm
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dtnb
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fluke
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sjtgr
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fasciola
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oxadiazole
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cysticerci
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hysteretic
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medicine
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taenia
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trematode
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echinococcus
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granulosus
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schistosomicidal
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crassiceps
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gigantica
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selenocysteine-containing
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furoxans
-
analysis
- 1.8.1.B1
- schistosoma
- schistosomiasis
- worm
- mansoni
- praziquantel
- glutaredoxin
- selenocysteine
-
antischistosomal
- gssg
- auranofin
-
platyhelminth
- flatworm
- dtnb
- fluke
-
sjtgr
- fasciola
-
oxadiazole
- cysticerci
-
hysteretic
- medicine
-
taenia
-
trematode
-
echinococcus
- granulosus
-
schistosomicidal
- crassiceps
- gigantica
-
selenocysteine-containing
- furoxans
- analysis
Reaction
Synonyms
cTGR, DmTrxR, EgTGR, mTGR, SmTGR, TGR, TGRsec, thioredoxin glutathione reductase, thioredoxin-glutathione reductase, thioredoxin/glutathione reductase
ECTree
1.8.1.B1 thioredoxin glutathione reductaseAdvanced search results
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results (KM Value
KM Value on EC 1.8.1.B1 - thioredoxin glutathione reductase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2.792
2-hydroxyethyl disulfide
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at 25°C in 0.1 M potassium phosphate (pH 7.4)
additional information
additional information
-
kinetic properties of the Grx domain of TGR
-
0.033
5,5'-dithio-bis(2-nitrobenzoic acid)
-
mutant C574S, pH 7.0, temperature not specified in the publication
0.034
5,5'-dithio-bis(2-nitrobenzoic acid)
-
mutant C519S, pH 7.0, temperature not specified in the publication
0.038
5,5'-dithio-bis(2-nitrobenzoic acid)
-
wild-type, pH 7.0, temperature not specified in the publication
0.00434
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH not specified in the publication, temperature not specified in the publication
0.043
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.045
5,5'-dithiobis(2-nitrobenzoic acid)
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.088
5,5'-dithiobis(2-nitrobenzoic acid)
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.107
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.1451
5,5'-dithiobis(2-nitrobenzoic acid)
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at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.169
5,5'-dithiobis(2-nitrobenzoic acid)
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mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.187
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.23
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.23
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.319
5,5'-dithiobis(2-nitrobenzoic acid)
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.375
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.406
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.004
glutathione disulfide
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.0063
glutathione disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.012
glutathione disulfide
-
mutant C519S, pH 7.0, temperature not specified in the publication
0.013
glutathione disulfide
-
mutant C574S, pH 7.0, temperature not specified in the publication
0.015
glutathione disulfide
-
wild-type, pH 7.0, temperature not specified in the publication
0.0612
glutathione disulfide
-
pH not specified in the publication, temperature not specified in the publication
0.184
glutathione-hydroxyethyl disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.41
glutathione-hydroxyethyl disulfide
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.013
GSSG
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.016
GSSG
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.023
GSSG
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.024
GSSG
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.031
GSSG
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.036
GSSG
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.042
GSSG
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.071
GSSG
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.189
GSSG
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.012
mitochondial thioredoxin
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pH 7.0, 25°C, Sec-to-Cys mutant enzyme
0.0016
NADPH
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mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.0051
NADPH
mutant enzyme U642C, cosubstrate: thioredoxin disulfide, pH 7.4, 25°C
0.01097
NADPH
-
with glutaredoxin as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.0166
NADPH
recombinant wild-type enzyme, cosubstrate: thioredoxin disulfide, pH 7.4, 25°C
0.0208
NADPH
recombinant wild-type enzyme, cosubstrate: glutathione disulfide, pH 6.9, 25°C
0.02142
NADPH
-
with 5,5'-dithiobis(2-nitrobenzoic acid) as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.048
NADPH
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.08324
NADPH
-
with GSSG as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.00324
thioredoxin disulfide
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.007
thioredoxin disulfide
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.007
thioredoxin disulfide
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.008
thioredoxin disulfide
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.008
thioredoxin disulfide
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.008
thioredoxin disulfide
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.015
thioredoxin disulfide
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.015
thioredoxin disulfide
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.019
thioredoxin disulfide
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.022
thioredoxin disulfide
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.067
thioredoxin disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
