1.8.1.B1: thioredoxin glutathione reductase
This is an abbreviated version!
For detailed information about thioredoxin glutathione reductase, go to the full flat file.
Word Map on EC 1.8.1.B1
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1.8.1.B1
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schistosoma
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schistosomiasis
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worm
-
mansoni
-
praziquantel
-
glutaredoxin
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selenocysteine
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antischistosomal
-
gssg
-
auranofin
-
platyhelminth
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flatworm
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dtnb
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fluke
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sjtgr
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fasciola
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oxadiazole
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cysticerci
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hysteretic
-
medicine
-
taenia
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trematode
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echinococcus
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granulosus
-
schistosomicidal
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crassiceps
-
gigantica
-
selenocysteine-containing
-
furoxans
-
analysis
- 1.8.1.B1
- schistosoma
- schistosomiasis
- worm
- mansoni
- praziquantel
- glutaredoxin
- selenocysteine
-
antischistosomal
- gssg
- auranofin
-
platyhelminth
- flatworm
- dtnb
- fluke
-
sjtgr
- fasciola
-
oxadiazole
- cysticerci
-
hysteretic
- medicine
-
taenia
-
trematode
-
echinococcus
- granulosus
-
schistosomicidal
- crassiceps
- gigantica
-
selenocysteine-containing
- furoxans
- analysis
Reaction
Synonyms
cTGR, DmTrxR, EgTGR, mTGR, SmTGR, TGR, TGRsec, thioredoxin glutathione reductase, thioredoxin-glutathione reductase, thioredoxin/glutathione reductase
ECTree
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Turnover Number on EC 1.8.1.B1 - thioredoxin glutathione reductase
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
8.65
2-hydroxyethyl disulfide
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
10.2
5,5'-dithio-bis(2-nitrobenzoic acid)
-
mutant C574S, pH 7.0, temperature not specified in the publication
12
5,5'-dithio-bis(2-nitrobenzoic acid)
-
mutant C519S, pH 7.0, temperature not specified in the publication
55
5,5'-dithio-bis(2-nitrobenzoic acid)
-
wild-type, pH 7.0, temperature not specified in the publication
1.85
5,5'-dithiobis(2-nitrobenzoic acid)
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
4
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
5
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
8
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
8.16
5,5'-dithiobis(2-nitrobenzoic acid)
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
12.6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
16
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
16
5,5'-dithiobis(2-nitrobenzoic acid)
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
118
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH 7.0, 25°C, wild-type enzyme
0.96
glutathione disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
1.62
glutathione disulfide
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
2 - 8
glutathione disulfide
-
wild-type, pH 7.0, temperature not specified in the publication
5
glutathione disulfide
-
mutant C574S, pH 7.0, temperature not specified in the publication
5.6
glutathione disulfide
-
mutant C519S, pH 7.0, temperature not specified in the publication
5.13
glutathione-hydroxyethyl disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
163.5
glutathione-hydroxyethyl disulfide
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.6
GSSG
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.7
GSSG
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
3.5
GSSG
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
4
GSSG
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
5
GSSG
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
5
GSSG
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
7
GSSG
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
19.4
GSSG
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
25
GSSG
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6.4
mitochondial thioredoxin
-
pH 7.0, 25°C, Sec-to-Cys mutant enzyme
0.015
NADPH
25°C, pH 7.4, mutant enzyme U642C, cosubstrate: thioredoxin disulfide
0.14
NADPH
25°C, pH 6.9, recombinant wild-type enzyme, cosubstrate: thioredoxin disulfide
0.2
NADPH
25°C, pH 7.4, recombinant wild-type enzyme, cosubstrate: thioredoxin disulfide
1.64
NADPH
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
4.87
NADPH
-
with GSSG as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
10.92
NADPH
-
with 5,5'-dithiobis(2-nitrobenzoic acid) as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
12.6
NADPH
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
14.93
NADPH
-
with glutaredoxin as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.35
thioredoxin disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
3.5
thioredoxin disulfide
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
4.78
thioredoxin disulfide
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
8
thioredoxin disulfide
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
8
thioredoxin disulfide
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
9
thioredoxin disulfide
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
