1.8.1.B1: thioredoxin glutathione reductase
This is an abbreviated version!
For detailed information about thioredoxin glutathione reductase, go to the full flat file.
Word Map on EC 1.8.1.B1
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1.8.1.B1
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schistosoma
-
schistosomiasis
-
worm
-
mansoni
-
praziquantel
-
glutaredoxin
-
selenocysteine
-
antischistosomal
-
gssg
-
auranofin
-
platyhelminth
-
flatworm
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dtnb
-
fluke
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sjtgr
-
fasciola
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oxadiazole
-
cysticerci
-
hysteretic
-
medicine
-
taenia
-
trematode
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echinococcus
-
granulosus
-
schistosomicidal
-
crassiceps
-
gigantica
-
selenocysteine-containing
-
furoxans
-
analysis
- 1.8.1.B1
- schistosoma
- schistosomiasis
- worm
- mansoni
- praziquantel
- glutaredoxin
- selenocysteine
-
antischistosomal
- gssg
- auranofin
-
platyhelminth
- flatworm
- dtnb
- fluke
-
sjtgr
- fasciola
-
oxadiazole
- cysticerci
-
hysteretic
- medicine
-
taenia
-
trematode
-
echinococcus
- granulosus
-
schistosomicidal
- crassiceps
- gigantica
-
selenocysteine-containing
- furoxans
- analysis
Reaction
Synonyms
cTGR, DmTrxR, EgTGR, mTGR, SmTGR, TGR, TGRsec, thioredoxin glutathione reductase, thioredoxin-glutathione reductase, thioredoxin/glutathione reductase
ECTree
1.8.1.B1 thioredoxin glutathione reductaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.8.1.B1 - thioredoxin glutathione reductase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5,5'-dithio-bis(2-nitrobenzoic acid) + NADPH + H+
5'-thionitrobenzoic acid + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
beta-hydroxyethyl disulfide + NADPH + H+
2 2-sulfanylethan-1-ol + NADP+
-
-
-
-
?
cytosolic thioredoxin + NADP+
cytosolic thioredoxin disulfide + NADPH
-
-
-
-
r
glutathione-hydroxyethyl disulfide + NADPH + H+
glutathione + 2-sulfanylethan-1-ol + NADP+
-
-
-
-
?
mitochondrial thioredoxin + NADP+
mitochondrial thioredoxin disulfide + NADPH
-
-
-
-
r
thioredoxin disulfide + NADPH
thioredoxin + NADP+
-
absolute specificity for NADPH as electron donor
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
absolute specificity for NADPH as electron donor
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
enzyme displays hysteretic behavior
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
the enzyme of the parasite essential for the survival of schistosomes in the mammalian host
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
the enzyme follows a two-site ping-pong bi bi kinetic mechanism, in which both substrates and products are bound in rapid equilibrium fashion
-
-
?
GSSG + NADPH + H+
glutathione + NADP+
-
absolute specificity for NADPH as electron donor
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
the enzyme of the parasite essential for the survival of schistosomes in the mammalian host
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
the enzyme follows a two-site ping-pong bi bi kinetic mechanism, in which both substrates and products are bound in rapid equilibrium fashion
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
Escherichia coli thioredoxin disulfide
-
-
?
additional information
?
-
-
the glutathione reductase activity of TGR exhibits hysteretic behavior regulated by the [GSSG]/[GSH] ratio. This behavior is associated with glutathionylation by GSSG and abolished by deglutathionylation
-
-
?
additional information
?
-
-
TGR promotes isomerization of disulfide bonds formed between glutathione peroxidase 4 and certain sperm proteins, generating a 46-kDa species containing glutathione peroxidase 4 from high molecular weight nonspecific cross-links
-
-
?
additional information
?
-
-
the parasite-specific enzyme thioredoxin glutathione reductase is a component of the defense system
-
-
?
