1.1.1.83: D-malate dehydrogenase (decarboxylating)

This is an abbreviated version, for detailed information about D-malate dehydrogenase (decarboxylating), go to the full flat file.

Reaction

(R)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

D-malate dehydrogenase, D-malic enzyme, dehydrogenase, D-malate (decarboxylating), dmlA

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.83 D-malate dehydrogenase (decarboxylating)

Expression

Expression on EC 1.1.1.83 - D-malate dehydrogenase (decarboxylating)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
addition of nitrate during anaerobic growth represses the expression of dmlA-lacZ about 2.2fold, but the expression is still higher than the expression under aerobic conditions. The presence of glucose during anaerobic growth represses dmlA expression to levels similar to those observed after nitrate addition, suggesting that there is some glucose repression (2.4fold)
in a wild-type background, D-malate and meso- and L-tartrate cause high levels of induction of dmlA-lacZ expression (up to 12.3fold). With L-malate, succinate, and D-tartrate there is only weak induction. Induction of dmlA encoding DmlA requires an intact dmlR gene, which encodes DmlR, a LysR-type transcriptional regulator; the expression of dmlA-lacZ at high levels is induced under anaerobic conditions in the presence of D-malate and is more than 5fold greater than the expression under aerobic conditions