1.1.1.71: alcohol dehydrogenase [NAD(P)+]

This is an abbreviated version, for detailed information about alcohol dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

a primary alcohol
+
NAD(P)+
=
an aldehyde
+
NAD(P)H
+
H+

Synonyms

ADH, ADH12, ADH2, Adh319, AdhE, aldehyde reductase (NADPH/NADH), HvADH2, HVO_B0071, retinal reductase, retinaldehyde reductase, Retinol dehydrogenase, retinol-active alcohol dehydrogenase, TsAdh319, Tsib_0319, VNG_2617G

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.71 alcohol dehydrogenase [NAD(P)+]

Crystallization

Crystallization on EC 1.1.1.71 - alcohol dehydrogenase [NAD(P)+]

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Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2.15 A resolution, tetramer of 222 symmetry, the monomer is composed of a cofactor-binding domain and a catalytic domain, it contains a single zinc atom in the putative active side, the tetramer is composed of two dimers
-
2.05 A resolution, tetramer of 222 symmetry, the monomer is composed of a cofactor-binding domain and a catalytic domain, it contains a single zinc atom in the putative active side, the tetramer is composed of two dimers
-
hanging-drop vapour-diffusion method using 25% (w/v) polyethylene glycol 3350 pH 7.5 as precipitant; to 1.68 A resolution, crystals belong to space group I222, with unit-cell parameters a = 55.63, b = 83.25, c = 120.75 A
-