1.1.1.71: alcohol dehydrogenase [NAD(P)+]

This is an abbreviated version, for detailed information about alcohol dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

a primary alcohol
+
NAD(P)+
=
an aldehyde
+
NAD(P)H
+
H+

Synonyms

ADH, ADH12, ADH2, Adh319, AdhE, aldehyde reductase (NADPH/NADH), HvADH2, HVO_B0071, retinal reductase, retinaldehyde reductase, Retinol dehydrogenase, retinol-active alcohol dehydrogenase, TsAdh319, Tsib_0319, VNG_2617G

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.71 alcohol dehydrogenase [NAD(P)+]

Inhibitors

Inhibitors on EC 1.1.1.71 - alcohol dehydrogenase [NAD(P)+]

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
slight inhibition
4-chloromercuribenzoate
8-hydroxyquinoline
-
1 mM, 100% inhibition with NAD+ as cofactor, 40% with NADP+ as cofactor
acetonitrile
-
complete inhibition in buffer without NaCl and in buffer with 600 mM NaCl
AgNO3
-
1 mM, 100% inhibition
CdCl2
-
1 mM, 24% inhibition with NAD+ as cofactor
Chloroform
-
21% inhibition in buffer without NaCl, 19% inhibition in buffer with 600 mM NaCl
CuSO4
-
1 mM, 75% inhibition with NAD+ as cofactor, 56% with NADP+ as cofactor
Dimethyl formamide
-
87% inhibition in buffer without NaCl, 59% inhibition in buffer with 600 mM NaCl
dimethyl sulfoxide
-
complete inhibition in buffer without NaCl, 60% inhibition in buffer with 600 mM NaCl
ethyl acetate
-
complete inhibition in buffer without NaCl, 67% inhibition in buffer with 600 mM NaCl
Fe2+
-
10 mM, 74% of initial activity
FeSO4
HgCl2
-
1 mM, 100% inhibition
iodoacetamide
-
1 mM, complete inhibition
iodoacetic acid
-
1 mM, 29% inhibition with NAD+ as cofactor, 80% with NADP+ as cofactor
methanol
-
75% inhibition in buffer without NaCl, 81% inhibition in buffer with 600 mM NaCl
Mg2+
-
10 mM, 78% of initial activity
n-decane
-
9% inhibition in buffer without NaCl, slight activation in buffer with 600 mM NaCl
N-ethylmaleimide
n-hexane
-
40% inhibition in buffer without NaCl, slight activation in buffer with 600 mM NaCl
o-phenanthroline
p-hydroxymercuribenzoate
-
strong inhibition
Phenobarbital
-
0.5 mM, 30% inhibition
pyrazole
-
0.5 mM, 35% inhibition
Sodium azide
-
10 mM, 40% inhibition
Sodium glycocholate
-
-
Tween 80
-
-
Zn2+
-
10 mM, 79% of initial activity
ZnSO4
-
10 mM, 21% inhibition