1.1.1.71: alcohol dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about alcohol dehydrogenase [NAD(P)+], go to the full flat file.
Word Map on EC 1.1.1.71
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1.1.1.71
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retinoids
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thermoanaerobacter
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all-trans-retinaldehyde
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retinyl
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ethanolicus
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all-trans-retinol
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r-1-phenylethanol
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cyp26a1
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akr1b10
- 1.1.1.71
-
retinoids
- thermoanaerobacter
- all-trans-retinaldehyde
-
retinyl
-
ethanolicus
- all-trans-retinol
-
r-1-phenylethanol
-
cyp26a1
- akr1b10
Reaction
Synonyms
ADH, ADH12, ADH2, Adh319, AdhA, AdhE, alcohol dehydrogenase, aldehyde reductase (NADPH/NADH), DHRS3, HvADH2, HVO_B0071, NAD(P)+-dependent alcohol dehydrogenase, NAD(P)H-dependent ADH, NAD(P)H-dependent aldehyde reductase, NADPH-dependent ADHA, NADPH-dependent alcohol dehydrogenase, PH0743, PhADH, RADH, retinal reductase, retinal short-chain dehydrogenase/reductase member 3, retinaldehyde reductase, Retinol dehydrogenase, retinol-active alcohol dehydrogenase, retSDR1, TeSADH, TsAdh319, Tsib_0319, VNG_2617G, YqhD
ECTree
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Inhibitors
Inhibitors on EC 1.1.1.71 - alcohol dehydrogenase [NAD(P)+]
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8-hydroxyquinoline
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1 mM, 100% inhibition with NAD+ as cofactor, 40% with NADP+ as cofactor
acetonitrile
complete inhibition in buffer without NaCl and in buffer with 600 mM NaCl
chloroform
21% inhibition in buffer without NaCl, 19% inhibition in buffer with 600 mM NaCl
CuSO4
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1 mM, 75% inhibition with NAD+ as cofactor, 56% with NADP+ as cofactor
Dimethyl formamide
87% inhibition in buffer without NaCl, 59% inhibition in buffer with 600 mM NaCl
dimethyl sulfoxide
complete inhibition in buffer without NaCl, 60% inhibition in buffer with 600 mM NaCl
ethyl acetate
complete inhibition in buffer without NaCl, 67% inhibition in buffer with 600 mM NaCl
iodoacetic acid
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1 mM, 29% inhibition with NAD+ as cofactor, 80% with NADP+ as cofactor
methanol
75% inhibition in buffer without NaCl, 81% inhibition in buffer with 600 mM NaCl
n-decane
9% inhibition in buffer without NaCl, slight activation in buffer with 600 mM NaCl
n-hexane
40% inhibition in buffer without NaCl, slight activation in buffer with 600 mM NaCl
4-chloromercuribenzoate
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0.01 mM, complete inhibition; some protection of partial inhibition resulting from 0.001 mM 4-chloromercuribenzoate in the presence of 1 mM NADP+, almost complete protection with 10 mM hexan-1-ol
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1 mM, 75% inhibition with NAD+ as cofactor, 46% with NADP+ as cofactor
o-phenanthroline
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1 mM, 100% inhibition with NAD+ as cofactor, 40% with NADP+ as cofactor
the Fe2+-reconstituted Ni-PhADH was sensitively and rapidly inactivated by dioxygen gas. The enzyme is inactivated by the replacement of the ferrous ion in the active site with another metal ion such as a zinc ion, which has been considered an inhibitor of iron-activating group III ADHs
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additional information
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dithiothreitol and EDTA have no effect on either oxidative or reductive activity
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