1.1.1.71: alcohol dehydrogenase [NAD(P)+]

This is an abbreviated version, for detailed information about alcohol dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

a primary alcohol
+
NAD(P)+
=
an aldehyde
+
NAD(P)H
+
H+

Synonyms

ADH, ADH12, ADH2, Adh319, AdhE, aldehyde reductase (NADPH/NADH), HvADH2, HVO_B0071, retinal reductase, retinaldehyde reductase, Retinol dehydrogenase, retinol-active alcohol dehydrogenase, TsAdh319, Tsib_0319, VNG_2617G

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.71 alcohol dehydrogenase [NAD(P)+]

Substrates Products

Substrates Products on EC 1.1.1.71 - alcohol dehydrogenase [NAD(P)+]

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S,5S)-2,5-hexanediol + NADP+
? + NADPH + H+
show the reaction diagram
(S)-2-butanol + NADP+
butanone + NADPH
show the reaction diagram
-
196% relative activity as compared to 2-propanol
-
-
?
(S)-2-butanol + NADP+
butanone + NADPH + H+
show the reaction diagram
-
196% of the activity with 2-propanol, 2fold preference for (S)-2-butanol over (RS)-2-butanol
-
-
?
1,3-butanediol + NADP+
? + NADPH + H+
show the reaction diagram
-
91% relative activity as compared to 2-propanol
-
-
?
1-butanol + NADP+
1-butanal + NADPH + H+
show the reaction diagram
-
-
-
?
1-butanol + NADP+
butanal + NADPH
show the reaction diagram
-
80% relative activity as compared to 2-propanol
-
-
?
1-butanol + NADP+
butanal + NADPH + H+
show the reaction diagram
1-pentanol + NADP+
pentanal + NADPH + H+
show the reaction diagram
1-phenylethanol + NADP+
1-phenylethanone + NADPH + H+
show the reaction diagram
35% of the activtiy with 1-propanol
-
-
?
1-phenylethanol + NADP+
acetophenone + NADPH + H+
show the reaction diagram
35% compared to activity with 1-propanol
-
-
?
1-phenylmethanol + NADP+
benzaldehyde + NADPH + H+
show the reaction diagram
-
180% relative activity as compared to 2-propanol
-
-
?
1-propanol + NAD+
propanal + NADH + H+
show the reaction diagram
dual cofactor dependency, NAD+ shows 60% of the activity with NADP+
-
-
?
1-propanol + NADP+
propanal + NADPH + H+
show the reaction diagram
2,3-pentanedione + NADPH + H+
? + NADP+
show the reaction diagram
2-butanol + NADP+
2-butanone + NADPH + H+
show the reaction diagram
43% of the activity compared to ethanol
-
-
-
2-butanol + NADP+
butanone + NADPH + H+
show the reaction diagram
2-hydroxy-3-methoxybenzaldehyde + NADPH + H+
2-hydroxy-3-methoxybenzyl alcohol + NADP+
show the reaction diagram
-
-
-
?
2-methoxybenzaldehyde + NADPH + H+
2-methoxybenzalcohol + NADP+
show the reaction diagram
highest activity
-
-
?
2-pentanol + NADP+
2-pentanone + NADPH + H+
show the reaction diagram
-
67% relative activity as compared to 2-propanol
-
-
?
2-pentanol + NADP+
pentan-2-one + NADPH + H+
show the reaction diagram
-
67% of the activity with 2-propanol
-
-
?
2-propanol + NADP+
acetone + NADPH
show the reaction diagram
2-propanol + NADP+
acetone + NADPH + H+
show the reaction diagram
3,4-dimethoxybenzaldehyde + NADPH + H+
3,4-dimethoxybenzyl alcohol + NADP+
show the reaction diagram
-
-
-
?
3-methyl-2-pentanone + NADPH + H+
? + NADP+
show the reaction diagram
-
13% relative activity as compared to pyruvaldehyde
-
-
?
3-methylbutanal + NADP+
? + NADPH + H+
show the reaction diagram
about% of the activity with 1-butanol
-
-
?
4-methoxybenzaldehyde + NADPH + H+
4-methoxybenzalcohol + NADP+
show the reaction diagram
-
-
-
?
acetaldehyde + NADH + H+
ethanol + NAD+
show the reaction diagram
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
all-trans-retinol + NADP+
all-trans-retinal + NADPH + H+
show the reaction diagram
-
-
-
r
allyl alcohol + NADP+
acrylaldehyde + NADPH
show the reaction diagram
benzaldehyde + NAD(P)H
benzyl alcohol + NAD(P)+
show the reaction diagram
-
-
-
?
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
show the reaction diagram
-
-
-
?
benzyl alcohol + NADP+
benzaldehyde + NADPH
show the reaction diagram
-
-
-
r
benzyl alcohol + NADP+
benzaldehyde + NADPH + H+
show the reaction diagram
butan-1,4-diol + NADP+
butandialdehyde + NADPH
show the reaction diagram
-
29% of activity with hexan-1-ol
-
r
butan-1-ol + NADP+
butanal + NADPH
show the reaction diagram
butanal + NAD(P)H + H+
butan-1-ol + NAD(P)+
show the reaction diagram
-
-
-
?
cellobiose + NADP+
? + NADPH + H+
show the reaction diagram
cinnamaldehyde + NADPH + H+
cinnamyl alcohol + NADP+
show the reaction diagram
-
-
-
?
cis-2-butenol + NAD(P)H
trans-2-butenal + NAD(P)+
show the reaction diagram
cis-4-heptenal + NAD(P)+
cis-4-heptenol + NAD(P)H
show the reaction diagram
-
-
-
?
cis-hex-3-en-1-ol + NADP+
cis-hex-3-en-1-al + NADPH
show the reaction diagram
-
18.7% of activity with hexan-1ol
-
r
citral + NAD(P)H
citrol + NAD(P)+
show the reaction diagram
-
-
-
?
D-arabinose + NADP+
? + NADPH + H+
show the reaction diagram
-
200% relative activity as compared to 2-propanol
-
-
?
D-arabinose + NADP+
D-arabitol + NADPH + H+
show the reaction diagram
-
200% of the activity with 2-propanol. D-arabinose is preferred over L-arabinose
-
-
?
D-glucose + NADP+
? + NADPH + H+
show the reaction diagram
D-mannose + NADP+
? + NADPH + H+
show the reaction diagram
-
48% relative activity as compared to 2-propanol
-
-
?
D-ribose + NADP+
? + NADPH + H+
show the reaction diagram
-
35% relative activity as compared to 2-propanol
-
-
?
D-xylose + NADP+
? + NADPH + H+
show the reaction diagram
decan-1-ol + NADP+
decanal + NADPH
show the reaction diagram
-
decrease in enzyme activity with increase in chain length
-
r
decanal + NAD(P)H
decan-1-ol + NAD(P)+
show the reaction diagram
-
-
-
?
dimethylglyoxal + NADPH + H+
? + NADP+
show the reaction diagram
dodecan-1-ol + NADP+
dodecanal + NADPH
show the reaction diagram
-
decrease in enzyme activity with increase in chain length
-
r
dodecanal + NAD(P)H
dodecan-1-ol + NAD(P)+
show the reaction diagram
-
-
-
?
ethanal + NAD(P)H
ethanol + NAD(P)+
show the reaction diagram
-
-
-
?
ethanediol + NADP+
glyoxal + NADPH
show the reaction diagram
ethanol + NAD+
acetaldehyde + NADH + H+
show the reaction diagram
enzyme appears to preferentially catalyze the reductive reaction. Activity with NAD+ is 75% less than that detected with NADP+
-
-
?
ethanol + NADP+
acetaldehyde + NADPH + H+
show the reaction diagram
ethanol + NADP+
ethanal + NADPH + H+
show the reaction diagram
farnesyl aldehyde + NAD(P)H
farnesol + NAD(P)+
show the reaction diagram
-
-
-
?
glycerol + NADP+
glyceraldehyde + NADPH + H+
show the reaction diagram
-
16% relative activity as compared to 2-propanol
-
-
?
glyoxylic acid + NADPH + H+
? + NADP+
show the reaction diagram
-
36% relative activity as compared to pyruvaldehyde
-
-
?
heptan-1-ol + NADP+
heptanal + NADPH
show the reaction diagram
-
-
-
r
heptanal + NAD(P)H
heptan-1-ol + NAD(P)+
show the reaction diagram
-
-
-
?
hexan-1-ol + NADP+
hexanal + NADPH
show the reaction diagram
hexanal + NADPH + H+
hexanol + NADP+
show the reaction diagram
-
-
-
?
hydrocinnamaldehyde + NADPH + H+
hydrocinnamyl alcohol + NADP+
show the reaction diagram
-
-
-
?
isoamyl alcohol + NADP+
? + NADPH + H+
show the reaction diagram
about 80% of the activity with 1-butanol
-
-
?
L-arabinose + NADP+
? + NADPH + H+
show the reaction diagram
-
17% relative activity as compared to 2-propanol
-
-
?
linolenyl aldehyde + NAD(P)H
linolenol + NAD(P)+
show the reaction diagram
-
-
-
?
linoleyl aldehyde + NAD(P)H
linoleol + NAD(P)+
show the reaction diagram
-
-
-
?
mannitol + NADP+
D-mannose + NADPH
show the reaction diagram
-
6.5% of activity with hexan-1-ol
-
r
methylglyoxal + NADPH
2-hydroxy-propanal + NADPH
show the reaction diagram
-
-
-
?
octan-1-ol + NADP+
octanal + NADPH
show the reaction diagram
-
decrease in enzyme activity with increase in chain length
-
r
octanal + NAD(P)H + H+
octan-1-ol + NAD(P)+
show the reaction diagram
-
-
-
?
octanal + NADPH + H+
octanol + NADP+
show the reaction diagram
-
-
-
?
oleyl aldehyde + NAD(P)H
oleol + NAD(P)+
show the reaction diagram
-
-
-
?
pentan-1-ol + NADP+
pentanal + NADPH
show the reaction diagram
propan-1-ol + NADP+
propanal + NADPH
show the reaction diagram
pyruvaldehyde + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
?
pyruvaldehyde + NADPH + H+
lactaldehyde + NADP+
show the reaction diagram
retinal + NAD(P)H
retinol + NAD(P)+
show the reaction diagram
-
-
-
?
retinaldehyde + NADH
retinol + NAD+
show the reaction diagram
ribitol + NADP+
D-ribose + NADPH
show the reaction diagram
-
4% of activity with hexan-1-ol
-
r
salicylaldehye + NADPH + H+
salicylalcohol + NADP+
show the reaction diagram
-
-
-
?
tetradecanal + NAD(P)H
tetradecan-1-ol + NAD(P)+
show the reaction diagram
-
-
-
?
trans-2,cis-6-nonadienal + NAD(P)+
trans-2,cis-6-nonadienol + NAD(P)H
show the reaction diagram
-
-
-
?
trans-2,cis-6-nonadienal + NADPH + H+
trans-2,cis-6-nonadienol + NADP+
show the reaction diagram
-
-
-
?
trans-2-hexenal + NADPH + H+
trans-2-hexenol + NADP+
show the reaction diagram
-
-
-
?
trans-2-nonenal + NADPH
trans-2-nonen-1-ol + NADPH
show the reaction diagram
-
-
-
?
trans-2-nonenal + NADPH + H+
trans-2-nonenol + NADP+
show the reaction diagram
-
-
-
?
trans-2-octenal + NADPH
trans-2-octen-1-ol + NADPH
show the reaction diagram
-
-
-
?
trans-2-pentenol + NAD(P)+
trans-2-pentenal + NAD(P)H
show the reaction diagram
-
-
-
?
trans-trans-2,4-decadienal + NADPH
trans-trans-2,4-decadienol + NADPH
show the reaction diagram
-
-
-
?
additional information
?
-