1.1.1.200: aldose-6-phosphate reductase (NADPH)

This is an abbreviated version, for detailed information about aldose-6-phosphate reductase (NADPH), go to the full flat file.

Reaction

D-sorbitol 6-phosphate
+
NADP+
=
D-glucose 6-phosphate
+
NADPH
+
H+

Synonyms

A6PR, A6PRase, alditol 6-phosphate:NADP 1-oxidoreductase, aldose-6-P reductase, aldose-6-phosphate reductase, aldose-6-phosphate reductase [NADPH], NADP-S6PDH, NADPH-dependent aldose 6-phosphate reductase, reductase, aldose 6-phosphate, S6PDH, sorbitol-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.200 aldose-6-phosphate reductase (NADPH)

Cloned

Cloned on EC 1.1.1.200 - aldose-6-phosphate reductase (NADPH)

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
amplified gene cloned into the pGEM-T Easy vector, heterologous expression with a His-tag alternatively placed in the N- or C-terminus in Escherichia coli BL21 Star (DE3) cells
‘Greensleeves’ apple is transformed with a cDNA encoding aldose 6-phosphate reductase in the antisense orientation. Antisense expression of A6PR decreases A6PR activity in mature leaves to approximately 15-30% of the untransformed control. The antisense plants have lower concentrations of sorbitol but higher concentrations of sucrose and starch in mature leaves at both dusk and predawn
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