1.1.1.200: aldose-6-phosphate reductase (NADPH)

This is an abbreviated version, for detailed information about aldose-6-phosphate reductase (NADPH), go to the full flat file.

Reaction

D-sorbitol 6-phosphate
+
NADP+
=
D-glucose 6-phosphate
+
NADPH
+
H+

Synonyms

A6PR, A6PRase, alditol 6-phosphate:NADP 1-oxidoreductase, aldose-6-P reductase, aldose-6-phosphate reductase, aldose-6-phosphate reductase [NADPH], NADP-S6PDH, NADPH-dependent aldose 6-phosphate reductase, reductase, aldose 6-phosphate, S6PDH, sorbitol-6-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.200 aldose-6-phosphate reductase (NADPH)

pH Range

pH Range on EC 1.1.1.200 - aldose-6-phosphate reductase (NADPH)

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 10
N- and the C-term tagged enzymes. Both recombinant enzymes similarly show optimal activity in a broad pH range in the direction of D-glucose 6-phosphate reduction, and a narrow range (pH 9.0-10.0) in the opposite oxidative direction
8.5 - 10.1
-
about 50% of activity maximum at pH 8.5 and 10.1