1.1.1.189: prostaglandin-E2 9-reductase

This is an abbreviated version, for detailed information about prostaglandin-E2 9-reductase, go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 9-keto-prostaglandin E2 reductase, 9-ketoprostaglandin reductase, 9-KPR, CBR1, More, mPGES, PG 9-ketoreductase/carbonyl reductase, PGE 9-ketoreductase, PGE2 9-ketoreductase, PGE2-9-K, PGE2-9-ketoreductase, PGE2-9-OR, prostaglandin 9-ketoreductase, prostaglandin 9-ketoreductase/carbonyl reductase, prostaglandin E 9-ketoreductase, prostaglandin E2 9-ketoreductase, prostaglandin E2-9-oxoreductase, prostaglandin-E2 9-keto reductase, reductase, 15-hydroxy9-oxoprostaglandin

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.189 prostaglandin-E2 9-reductase

Activating Compound

Activating Compound on EC 1.1.1.189 - prostaglandin-E2 9-reductase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
angiotensin I
-
at 0.1 mM concentration
ATP
-
at 1mM concentration slight stimulation
CTP
-
at 1mM concentration slight stimulation
gonadotropin-releasing hormone
-
-
GTP
-
at 1mM concentration slight stimulation
interferon tau
-
recombinant ovine interferon tau stimulates significantly prostaglandin E2 and prostaglandin F2alpha production at a concentration of 0.01 mg per ml
-
lipopolysaccharides
-
strong induction of the membrane-bound lung isozyme, significant induction in stomach, intestine, spleen, kidney, testis, and pancreas, overview
-
Oxytocin
Sodium diphosphate
-
-
additional information
-
aminoguanidine, an inducible nitric oxide synthase inhibitor, does not affect the enzyme, but activates L-NAME, a non-selective nitric oxide synthase inhibitor, thereby increasing prostaglandin F2alpha synthesis
-