1.1.1.189: prostaglandin-E2 9-reductase

This is an abbreviated version, for detailed information about prostaglandin-E2 9-reductase, go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 9-keto-prostaglandin E2 reductase, 9-ketoprostaglandin reductase, 9-KPR, CBR1, More, mPGES, PG 9-ketoreductase/carbonyl reductase, PGE 9-ketoreductase, PGE2 9-ketoreductase, PGE2-9-K, PGE2-9-ketoreductase, PGE2-9-OR, prostaglandin 9-ketoreductase, prostaglandin 9-ketoreductase/carbonyl reductase, prostaglandin E 9-ketoreductase, prostaglandin E2 9-ketoreductase, prostaglandin E2-9-oxoreductase, prostaglandin-E2 9-keto reductase, reductase, 15-hydroxy9-oxoprostaglandin

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.189 prostaglandin-E2 9-reductase

Reference

Reference on EC 1.1.1.189 - prostaglandin-E2 9-reductase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schieber, A.; Frank, R.W.; Ghisla, S.
Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase
Eur. J. Biochem.
206
491-502
1992
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Asselin, E.; Fortier, M.A.
Detection and regulation of the messenger for a putative bovine endometrial 9-keto-prostaglandin E2 reductase: effect of oxytocin and interferon-tau
Biol. Reprod.
62
125-131
2000
Bos taurus
Manually annotated by BRENDA team
Kankofer, M.; Wiercinski, J.
Prostaglandin E2 9-keto reductase from bovine term placenta
Prostaglandins Leukot. Essent. Fatty Acids
61
29-32
1999
Bos taurus
Manually annotated by BRENDA team
Gobbetti, A.; Zerani, M.
Amphibian oocyte: a model of a possible regulatory mechanism for prostaglandin E2 and prostaglandin F2.alpha. synthesis
J. Endocrinol.
145
235-241
1995
Triturus carnifex
Manually annotated by BRENDA team
Wintergalen, N.; Thole, H.H.; Galla, H.J.; Schlegel, W.
Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20.alpha-hydroxysteroid dehydrogenase activity
Eur. J. Biochem.
234
264-270
1995
Oryctolagus cuniculus
Manually annotated by BRENDA team
Oshige, T.; Ohtsuka, T.; Mibe, M.; Nagai, K.; Yamaguchi, M.; Ikenoue, T.; Mori, N.
Effects of saturated fatty acids on prostaglandin E 9-keto-reductase
Prostaglandins Leukot. Essent. Fatty Acids
45
245-247
1992
Homo sapiens
Manually annotated by BRENDA team
Schieber, A.; Ghisla, S.
Prostaglandin 9-ketoreductase from pig and human kidney: purification, properties and identity with human carbonyl reductase
Eicosanoids
5
S37-38
1992
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Schlegel, W.; Daniels, D.; Kruger, S.
Partial purification of prostaglandin E2-9-ketoreductase and prostaglandin-15-hydroxydehydrogenase from ovarian tissues of rabbits
Clin. Physiol. Biochem.
5
336-342
1987
Oryctolagus cuniculus
Manually annotated by BRENDA team
Kruger, S.; Schlegel, W.
Prostaglandin-E2 9-ketoreductase from human uterine decidua vera
Eur. J. Biochem.
157
481-485
1986
Homo sapiens
Manually annotated by BRENDA team
Schlegel, W.; Kruger, S.; Korte, K.
Purification of prostaglandin E2-9-oxoreductase from human decidua vera
FEBS Lett.
171
141-144
1984
Homo sapiens
Manually annotated by BRENDA team
Thuy, L.P.; Carpenter, M.P.
Prostaglandin E2-9-ketoreductase from rat testis
Biochem. Biophys. Res. Commun.
81
322-328
1978
Rattus norvegicus
Manually annotated by BRENDA team
Kaplan, L.; Lee, S.C.; Levine, L.
Partial purification and some properties of human erythrocyte prostaglandin 9-ketoreductase and 15-hydroxyprostaglandin dehydrogenase
Arch. Biochem. Biophys.
167
287-293
1975
Homo sapiens
Manually annotated by BRENDA team
Lee, S.C.; Levine, L.
Purification and regulatory properties of chicken heart prostaglandin E 9-ketoreductase
J. Biol. Chem.
250
4549-4555
1975
Gallus gallus
Manually annotated by BRENDA team
Stone, K.J.; Hart, M.
Prostaglandin-E2-9-ketoreductase in rabbit kidney
Prostaglandins
10
273-288
1975
Oryctolagus cuniculus
Manually annotated by BRENDA team
Nakashima, K.; Ueno, N.; Kamei, D.; Tanioka, T.; Nakatani, Y.; Murakami, M.; Kudo, I.
Coupling between cyclooxygenases and prostaglandin F(2alpha) synthase. Detection of an inducible, glutathione-activated, membrane-bound prostaglandin F2alpha-synthetic activity
Biochim. Biophys. Acta
1633
96-105
2003
Mus musculus
Manually annotated by BRENDA team
Watanabe, K.
Prostaglandin F synthase
Prostaglandins
68-69
401-407
2002
Bos taurus, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Sus scrofa
Manually annotated by BRENDA team
Kankofer, M.; Wiercinski, J.; Zerbe, H.
Prostaglandin E2 9-keto reductase activity in bovine retained and not retained placenta
Prostaglandins Leukot. Essent. Fatty Acids
66
413-417
2002
Bos taurus
Manually annotated by BRENDA team
Farina, M.G.; Billi, S.; Sordelli, M.S.; Ribeiro, M.L.; Di Girolamo, G.; Lombardi, E.; Franchi, A.M.
Nitric oxide (NO) inhibits prostaglandin E2 9-ketoreductase (9-KPR) activity in human fetal membranes
Prostaglandins Other Lipid Mediat.
79
260-270
2006
Homo sapiens
Manually annotated by BRENDA team
Waclawik, A.; Ziecik, A.J.
Differential expression of prostaglandin (PG) synthesis enzymes in conceptus during peri-implantation period and endometrial expression of carbonyl reductase/PG 9-ketoreductase in the pig
J. Endocrinol.
194
499-510
2007
Sus scrofa (Q28960)
Manually annotated by BRENDA team
Wasielak, M.; Glowacz, M.; Kaminska, K.; Waclawik, A.; Bogacki, M.
The influence of embryo presence on prostaglandins synthesis and prostaglandin E2 and F2alpha content in corpora lutea during periimplantation period in the pig
Mol. Reprod. Dev.
75
1208-1216
2008
Sus scrofa (Q28960)
Manually annotated by BRENDA team
Waclawik, A.; Jabbour, H.N.; Blitek, A.; Ziecik, A.J.
Estradiol-17beta, prostaglandin E2 (PGE2), and the PGE2 receptor are involved in PGE2 positive feedback loop in the porcine endometrium
Endocrinology
150
3823-3832
2009
Sus scrofa (Q28960)
Manually annotated by BRENDA team
Ziecik, A.J.; Waclawik, A.; Bogacki, M.
Conceptus signals for establishment and maintenance of pregnancy in pigs - lipid signaling system
Exp. Clin. Endocrinol. Diabetes
116
443-449
2008
Sus scrofa
Manually annotated by BRENDA team
Waclawik, A.; Kaczmarek, M.M.; Kowalczyk, A.E.; Bogacki, M.; Ziecik, A.J.
Expression of prostaglandin synthesis pathway enzymes in the porcine corpus luteum during the oestrous cycle and early pregnancy
Theriogenology
70
145-152
2008
Sus scrofa (Q28960)
Manually annotated by BRENDA team
Parillo, F.; Catone, G.; Maranesi, M.; Gobbetti, A.; Gasparrini, B.; Russo, M.; Boiti, C.; Zerani, M.
Immunolocalization, gene expression, and enzymatic activity of cyclooxygenases, prostaglandin e2-9-ketoreductase, and nitric oxide synthases in Mediterranean buffalo (Bubalus bubalis) corpora lutea during diestrus
Microsc. Res. Tech.
75
1682-1690
2012
Bubalus bubalis
Manually annotated by BRENDA team