BRENDA - Enzyme Database show
show all sequences of 1.1.1.189

Detection and regulation of the messenger for a putative bovine endometrial 9-keto-prostaglandin E2 reductase: effect of oxytocin and interferon-tau

Asselin, E.; Fortier, M.A.; Biol. Reprod. 62, 125-131 (2000)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
interferon tau
recombinant ovine interferon tau stimulates significantly prostaglandin E2 and prostaglandin F2alpha production at a concentration of 0.01 mg per ml
Bos taurus
Inhibitors
Inhibitors
Commentary
Organism
Structure
interferon tau
recombinant ovine interferon tau inhibits 25% prostaglandin E2 and prostaglandin F2alpha production at a concentration of 1 ng per ml
Bos taurus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
Bos taurus
together with PGF synthase this enzyme can be a key enzyme in the regulation of specific prostaglandines in the endometrium during the preimplantation period
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
epithelium
endometrial
Bos taurus
-
kidney
-
Bos taurus
-
liver
highest mRNA concentration
Bos taurus
-
ovary
-
Bos taurus
-
testis
-
Bos taurus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
389447
Bos taurus
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
together with PGF synthase this enzyme can be a key enzyme in the regulation of specific prostaglandines in the endometrium during the preimplantation period
389447
Bos taurus
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
-
-
-
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
interferon tau
recombinant ovine interferon tau stimulates significantly prostaglandin E2 and prostaglandin F2alpha production at a concentration of 0.01 mg per ml
Bos taurus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
interferon tau
recombinant ovine interferon tau inhibits 25% prostaglandin E2 and prostaglandin F2alpha production at a concentration of 1 ng per ml
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
Bos taurus
together with PGF synthase this enzyme can be a key enzyme in the regulation of specific prostaglandines in the endometrium during the preimplantation period
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
epithelium
endometrial
Bos taurus
-
kidney
-
Bos taurus
-
liver
highest mRNA concentration
Bos taurus
-
ovary
-
Bos taurus
-
testis
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
389447
Bos taurus
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
-
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
together with PGF synthase this enzyme can be a key enzyme in the regulation of specific prostaglandines in the endometrium during the preimplantation period
389447
Bos taurus
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
-
-
-
?
Other publictions for EC 1.1.1.189
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
725914
Parillo
Immunolocalization, gene expre ...
Bubalus bubalis
Microsc. Res. Tech.
75
1682-1690
2012
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1
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1
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-
-
-
-
-
-
-
697637
Waclawik
Estradiol-17beta, prostaglandi ...
Sus scrofa
Endocrinology
150
3823-3832
2009
-
-
-
-
-
-
-
-
-
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-
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1
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1
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1
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1
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689092
Wasielak
The influence of embryo presen ...
Sus scrofa
Mol. Reprod. Dev.
75
1208-1216
2008
-
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-
-
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-
-
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1
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1
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1
-
-
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-
-
-
-
-
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-
-
-
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-
-
-
-
697792
Ziecik
Conceptus signals for establis ...
Sus scrofa
Exp. Clin. Endocrinol. Diabetes
116
443-449
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
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-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
701271
Waclawik
Expression of prostaglandin sy ...
Sus scrofa
Theriogenology
70
145-152
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688008
Waclawik
Differential expression of pro ...
Sus scrofa
J. Endocrinol.
194
499-510
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
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-
-
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-
-
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-
-
1
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-
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-
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-
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-
-
1
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670733
Farina
Nitric oxide (NO) inhibits pro ...
Homo sapiens
Prostaglandins Other Lipid Mediat.
79
260-270
2006
1
-
-
-
-
-
1
-
1
-
-
1
-
2
-
-
-
-
-
3
-
-
1
-
1
-
-
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
3
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
654851
Nakashima
Coupling between cyclooxygenas ...
Mus musculus
Biochim. Biophys. Acta
1633
96-105
2003
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
11
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
1
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-
1
-
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1
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1
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11
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657211
Watanabe
Prostaglandin F synthase ...
Bos taurus, Gallus gallus, Homo sapiens, Oryctolagus cuniculus, Sus scrofa
Prostaglandins
68-69
401-407
2002
-
-
-
-
-
-
-
-
5
-
3
10
-
5
-
-
-
2
-
8
-
-
19
-
-
-
-
-
-
-
-
20
-
-
-
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-
-
20
-
-
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-
-
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-
5
-
3
10
-
-
-
-
-
8
-
-
19
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657212
Kankofer
Prostaglandin E2 9-keto reduct ...
Bos taurus
Prostaglandins Leukot. Essent. Fatty Acids
66
413-417
2002
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
389447
Asselin
Detection and regulation of th ...
Bos taurus
Biol. Reprod.
62
125-131
2000
1
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
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-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
389466
Kankofer
Prostaglandin E2 9-keto reduct ...
Bos taurus
Prostaglandins Leukot. Essent. Fatty Acids
61
29-32
1999
-
-
-
-
-
-
1
3
1
-
1
1
-
1
-
-
1
-
-
1
-
-
4
1
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
3
1
-
1
1
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-
1
-
1
-
-
4
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
389467
Gobbetti
Amphibian oocyte: a model of a ...
Triturus carnifex
J. Endocrinol.
145
235-241
1995
1
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
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-
-
1
-
-
1
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-
1
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1
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1
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1
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
389468
Wintergalen
Prostaglandin-E2 9-reductase f ...
Oryctolagus cuniculus
Eur. J. Biochem.
234
264-270
1995
-
-
-
-
-
-
1
6
2
-
1
-
-
2
-
-
1
-
-
2
1
-
3
1
1
-
-
-
2
-
-
1
1
-
-
-
-
-
1
-
-
-
-
1
1
6
2
-
1
-
-
-
-
1
-
2
1
-
3
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
347776
Schieber
Purification and properties of ...
Homo sapiens, Sus scrofa
Eur. J. Biochem.
206
491-502
1992
-
-
-
-
-
-
-
5
-
-
3
-
-
2
-
-
2
-
-
2
2
-
19
2
2
-
-
-
2
-
-
2
-
-
-
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-
-
2
-
-
-
-
-
-
5
-
-
3
-
-
-
-
2
-
2
2
-
19
2
2
-
-
-
2
-
-
-
-
-
-
-
-
-
389469
Oshige
Effects of saturated fatty aci ...
Homo sapiens
Prostaglandins Leukot. Essent. Fatty Acids
45
245-247
1992
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
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-
-
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1
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1
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1
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1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
389470
Schieber
Prostaglandin 9-ketoreductase ...
Homo sapiens, Sus scrofa
Eicosanoids
5
S37-38
1992
-
-
-
-
-
-
-
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-
1
3
-
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2
-
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2
-
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2
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8
2
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-
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-
3
-
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3
-
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1
3
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2
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2
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8
2
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389471
Schlegel
Partial purification of prosta ...
Oryctolagus cuniculus
Clin. Physiol. Biochem.
5
336-342
1987
-
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-
-
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-
1
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1
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1
-
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1
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-
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-
389472
Kruger
Prostaglandin-E2 9-ketoreducta ...
Homo sapiens
Eur. J. Biochem.
157
481-485
1986
2
-
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-
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-
5
2
-
-
2
1
-
1
-
-
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-
-
1
1
-
2
1
-
-
-
-
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1
3
-
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2
-
-
1
-
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5
3
2
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2
1
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1
1
-
2
1
-
-
-
-
-
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-
389473
Schlegel
Purification of prostaglandin ...
Homo sapiens
FEBS Lett.
171
141-144
1984
2
-
-
-
-
-
7
2
-
-
1
1
-
2
-
-
1
-
-
2
1
-
2
-
1
-
-
-
1
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1
-
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2
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1
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7
-
2
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1
1
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1
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2
1
-
2
-
1
-
-
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1
-
-
-
-
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-
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-
389474
Thuy
Prostaglandin E2-9-ketoreducta ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
81
322-328
1978
-
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5
-
2
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1
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1
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1
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1
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1
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1
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3
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3
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5
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2
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1
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1
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1
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1
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1
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389476
Kaplan
Partial purification and some ...
Homo sapiens
Arch. Biochem. Biophys.
167
287-293
1975
-
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-
-
-
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-
1
1
-
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1
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1
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-
1
1
-
4
-
1
-
1
-
2
-
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1
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1
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1
1
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1
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1
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4
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1
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1
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2
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389477
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Purification and regulatory pr ...
Gallus gallus
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4549-4555
1975
5
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2
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5
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1
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1
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2
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389478
Stone
Prostaglandin-E2-9-ketoreducta ...
Oryctolagus cuniculus
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1975
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