1.1.1.189: prostaglandin-E2 9-reductase

This is an abbreviated version, for detailed information about prostaglandin-E2 9-reductase, go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 9-keto-prostaglandin E2 reductase, 9-ketoprostaglandin reductase, 9-KPR, CBR1, More, mPGES, PG 9-ketoreductase/carbonyl reductase, PGE 9-ketoreductase, PGE2 9-ketoreductase, PGE2-9-K, PGE2-9-ketoreductase, PGE2-9-OR, prostaglandin 9-ketoreductase, prostaglandin 9-ketoreductase/carbonyl reductase, prostaglandin E 9-ketoreductase, prostaglandin E2 9-ketoreductase, prostaglandin E2-9-oxoreductase, prostaglandin-E2 9-keto reductase, reductase, 15-hydroxy9-oxoprostaglandin

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.189 prostaglandin-E2 9-reductase

Inhibitors

Inhibitors on EC 1.1.1.189 - prostaglandin-E2 9-reductase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
17beta-estradiol
5,5'-dithiobis(2-nitrobenzoate)
-
complete inhibition at 1 mM concentration
aspirin
-
equimolar to substrate inhibits 65% of enzyme activity
cortisol
Cu2+
-
5 mM concentration
FAD
-
5 mM concentration
Fentiazac
-
non competitive
indomethacin
interferon tau
-
recombinant ovine interferon tau inhibits 25% prostaglandin E2 and prostaglandin F2alpha production at a concentration of 1 ng per ml
-
lonazolac
-
equimolar to substrate inhibits 78% of enzyme activity
NAD+
-
5 mM concentration 60% inhibition, competitive
NADP+
-
5 mM concentration 60% inhibition, non-competitive
nitric oxide
-
inhibition e.g. by NOC-18, a NO donor
p-chloromercuribenzoate
-
complete inhibition at 1 mM concentration
palmitic acid
-
inhibits enzyme in dose-dependent manner
progesterone
prostaglandin E2
-
inhibits the reduction of 20alpha-hydroxy-pregn-4-en-3-one to progesterone competitively
Substance P
-
-
vitamin D3
-
equimolar to substrate inhibits 38% of enzyme activity
additional information
-
no effect: Mg2+, Ca2+, EDTA, EGTA, cAMP and cGMP
-