1.1.1.189: prostaglandin-E2 9-reductase

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For detailed information about prostaglandin-E2 9-reductase, go to the full flat file.

Reaction

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 9-keto-prostaglandin E2 reductase, 9-ketoprostaglandin reductase, 9-KPR, CBR1, More, mPGES, PG 9-ketoreductase/carbonyl reductase, PGE 9-ketoreductase, PGE2 9-ketoreductase, PGE2-9-K, PGE2-9-ketoreductase, PGE2-9-OR, prostaglandin 9-ketoreductase, prostaglandin 9-ketoreductase/carbonyl reductase, prostaglandin E 9-ketoreductase, prostaglandin E2 9-ketoreductase, prostaglandin E2-9-oxoreductase, prostaglandin-E2 9-keto reductase, reductase, 15-hydroxy9-oxoprostaglandin

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.189 prostaglandin-E2 9-reductase

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Results	in table
13	Activating Compound
30	AA Sequence
1	Application
1	CAS Registry Number
42	Cofactor
4	Disease/ Diagnostics
25	Inhibitors
4	Ki Value [mM]
21	KM Value [mM]
12	Localization
1	Metals/Ions
15	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
30	Organism
5	Pathway
9	PDB ID
14	pH Optimum
9	Purification (Commentary)
3	Reaction
3	Reaction Type
30	Reference
46	Source Tissue
8	Specific Activity [micromol/min/mg]
76	Substrates and Products (Substrate)
7	Subunits
35	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]

Disease

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Disease on EC 1.1.1.189 - prostaglandin-E2 9-reductase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Essential Hypertension

Effect of furosemide on renal prostaglandins E2 and F2 alpha in normal subjects and in patients with essential hypertension.

7364563

Placenta, Retained

Prostaglandin E(2) 9-keto reductase activity in bovine retained and not retained placenta.

12054911

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