1.1.1.189: prostaglandin-E2 9-reductase

This is an abbreviated version, for detailed information about prostaglandin-E2 9-reductase, go to the full flat file.

Reaction

(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate
+
NADP+
=
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
+
NADPH
+
H+

Synonyms

20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, 9-keto-prostaglandin E2 reductase, 9-ketoprostaglandin reductase, 9-KPR, CBR1, More, mPGES, PG 9-ketoreductase/carbonyl reductase, PGE 9-ketoreductase, PGE2 9-ketoreductase, PGE2-9-K, PGE2-9-ketoreductase, PGE2-9-OR, prostaglandin 9-ketoreductase, prostaglandin 9-ketoreductase/carbonyl reductase, prostaglandin E 9-ketoreductase, prostaglandin E2 9-ketoreductase, prostaglandin E2-9-oxoreductase, prostaglandin-E2 9-keto reductase, reductase, 15-hydroxy9-oxoprostaglandin

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.189 prostaglandin-E2 9-reductase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.189 - prostaglandin-E2 9-reductase

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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH
show the reaction diagram
prostaglandin E2 + NADPH
prostaglandin F2alpha + NADP+
show the reaction diagram
-
key enzyme responsible for the control of prostaglandin levels in placental tissues
-
-
r
prostaglandin E2 + NADPH + H+
prostaglandin F2alpha + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin H2 + NAD(P)H
prostaglandin E2 + NAD(P)+
show the reaction diagram
prostaglandin H2 + NAD(P)H
prostaglandin F2alpha + NAD(P)+
show the reaction diagram
prostaglandin H2 + NADPH
prostaglandin F2alpha + NADP+
show the reaction diagram
-
-
-
-
?