1.1.1.18: inositol 2-dehydrogenase

This is an abbreviated version, for detailed information about inositol 2-dehydrogenase, go to the full flat file.

Reaction

myo-inositol
+
NAD+
=
2,4,6/3,5-pentahydroxycyclohexanone
+
NADH
+
H+

Synonyms

BsIDH, IDH, inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, inositol dehydrogenase, iolG, MI dehydrogenase, More, myo-inositol 2-dehydrogenase, myo-inositol dehydrogenase, myo-inositol:NAD2 oxidoreductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.18 inositol 2-dehydrogenase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.18 - inositol 2-dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1-oxo-D-chiro-inositol + NADH + H+
D-chiro-inositol + NAD+
show the reaction diagram
D-2,3-diketo-4-deoxy-epi-inositol + NADH
ketodeoxyinositol + NAD+
show the reaction diagram
-
-
-
?
myo-inositol + NAD+
2,3,4,5,6-pentahydroxycyclohexanone + NADH + H+
show the reaction diagram
myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
show the reaction diagram
myo-inositol + NAD+
scyllo-inosose + NADH
show the reaction diagram
myo-inositol + NAD+
scyllo-inosose + NADH + H+
show the reaction diagram
pinitol + NADH + H+
?
show the reaction diagram
additional information
?
-
-
the enzyme shows a broad substrate spectrum while remaining highly stereoselective. BsIDH is able to oxidize the mono-saccharides alpha-D-glucose and alpha-D-xylose but not beta-D-glucose, D-mannose and D-galactose
-
-
-