1.1.1.18: inositol 2-dehydrogenase

This is an abbreviated version, for detailed information about inositol 2-dehydrogenase, go to the full flat file.

Reaction

myo-inositol
+
NAD+
=
2,4,6/3,5-pentahydroxycyclohexanone
 +
NADH
 +
H+

Synonyms

BsIDH, IDH, inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, inositol dehydrogenase, iolG, MI dehydrogenase, More, myo-inositol 2-dehydrogenase, myo-inositol dehydrogenase, myo-inositol:NAD2 oxidoreductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.18 inositol 2-dehydrogenase

Reference

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Reference on EC 1.1.1.18 - inositol 2-dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Berman, T.; Magasanik, B.
The pathway of myo-inositol degradation in Aerobacter aerogenes. Dehydrogenation and dehydration
J. Biol. Chem.
241
800-806
1966
Enterobacter aerogenes
Manually annotated by BRENDA team
Jiang, G.; Krishnan, A.H.; Kim, Y.W.; Wacek, T.J.; Krishnan, H.B.
A functional myo-inositol dehydrogenase gene is required for efficient nitrogen fixation and competitiveness of Sinorhizobium fredii USDA191 to nodulate soybean (Glycine max [L.] Merr.)
J. Bacteriol.
183
2595-2604
2001
Sinorhizobium fredii (Q9EZV8), Sinorhizobium fredii USDA191 (Q9EZV8)
Manually annotated by BRENDA team
Galbraith, M.P.; Feng, S.F.; Borneman, J.; Triplett, E.W.; de Bruijn, F.J.; Rossbach, S.
A functional myo-inositol catabolism pathway is essential for rhizopine utilization by Sinorhizobium meliloti
Microbiology
144
2915-2924
1998
Sinorhizobium meliloti (O68965)
Manually annotated by BRENDA team
Stein, R.; Schnarrenberger, C.; Gross, W.
myo-Inositol dehydrogenase from the acido- and thermophilic red alga Galdieria sulphuraria
Phytochemistry
46
17-20
1997
Galdieria sulphuraria
Manually annotated by BRENDA team
Fujita, Y.; Shindo, K.; Miwa, Y.; Yoshida, K.
Bacillus subtiltis inositol dehydrogenase-encoding gene (idh): sequence and expression in Escherichia coli
Gene
108
121-125
1991
Bacillus subtilis, Bacillus subtilis (P26935)
Manually annotated by BRENDA team
Ramaley, R.; Fujita, Y.; Freese, E.
Purification and properties of Bacillus subtilis inositol dehydrogenase
J. Biol. Chem.
254
7684-7690
1979
Bacillus subtilis
Manually annotated by BRENDA team
Fawole, M.O.
Inositol dehydrogenase from Serratia marcescens
Z. Allg. Mikrobiol.
16
327-328
1976
Serratia marcescens
Manually annotated by BRENDA team
Walker, J.B.
myo-Inositol:NAD+ 2-oxidoreductase
Methods Enzymol.
43
433-439
1975
Streptomyces hygroscopicus
Manually annotated by BRENDA team
Criddle, W.J.; Fry, J.C.; Keaney, M.M.
myo-Inositol dehydrogenase(s) from Acetomonas oxydans. Optimization of conditions for solubilization of membrane-bound enzyme
Biochem. J.
137
449-452
1974
Gluconobacter oxydans
Manually annotated by BRENDA team
Alizade, M.A.; Gaede, K.
Chirality of the hydrogen transfer to NAD catalyzed by myo-inositol dehydrogenase from Klebsiella pneumoniae
Z. Naturforsch. C
31
624-625
1976
Klebsiella pneumoniae
Manually annotated by BRENDA team
Vidal-Leiria, M.; Van Uden, N.
Inositol dehydrogenase from the yeast Cryptococcus melibiosum
Biochim. Biophys. Acta
293
295-303
1973
Myxozyma melibiosi
Manually annotated by BRENDA team
Yamakoshi, M.; Takahashi, M.; Kouzuma, T.; Imamura, S.; Tsuboi, I.; Kawazu, S.; Yamagata, F.; Tominaga, M.; Noritake, M.
Determination of urinary myo-inositol concentration by an improved enzymatic cycling method using myo-inositol dehydrogenase from Flavobacterium sp
Clin. Chim. Acta
328
163-171
2003
Flavobacterium sp.
Manually annotated by BRENDA team
Ono, M.; Nakajima, T.; Itoh, Y.; Shimada, K.; Yamato, S.
Specific determination of myo-inositol in multivitamin pharmaceutical preparations by a flow injection system using a myo-inositol dehydrogenase reactor coupled with a glucose eliminating enzyme reactor
J. Pharm. Biomed. Anal.
33
1175-1180
2003
Enterobacter aerogenes
Manually annotated by BRENDA team
Daniellou, R.; Palmer, D.R.
Appel-Lee synthesis of glycosyl inositols, substrates for inositol dehydrogenase from Bacillus subtilis
Carbohydr. Res.
341
2145-2150
2006
Bacillus subtilis
Manually annotated by BRENDA team
Daniellou, R.; Phenix, C.P.; Tam, P.H.; Laliberte, M.C.; Palmer, D.R.
Stereoselective oxidation of protected inositol derivatives catalyzed by inositol dehydrogenase from Bacillus subtilis
Org. Biomol. Chem.
3
401-403
2005
Bacillus subtilis, Bacillus subtilis (P26935)
Manually annotated by BRENDA team
Van Straaten, K.E.; Hoffort, A.; Palmer, D.R.; Sanders, D.A.
Purification, crystallization and preliminary X-ray analysis of inositol dehydrogenase (IDH) from Bacillus subtilis
Acta Crystallogr. Sect. F
64
98-101
2008
Bacillus subtilis
Manually annotated by BRENDA team
Yebra, M.J.; Zuniga, M.; Beaufils, S.; Perez-Martinez, G.; Deutscher, J.; Monedero, V.
Identification of a gene cluster enabling Lactobacillus casei BL23 to utilize myo-inositol
Appl. Environ. Microbiol.
73
3850-3858
2007
Lactobacillus casei
Manually annotated by BRENDA team
Daniellou, R.; Zheng, H.; Langill, D.M.; Sanders, D.A.; Palmer, D.R.
Probing the promiscuous active site of myo-inositol dehydrogenase using synthetic substrates, homology modeling, and active site modification
Biochemistry
46
7469-7477
2007
Bacillus subtilis, Bacillus subtilis (P26935)
Manually annotated by BRENDA team
van Straaten, K.E.; Zheng, H.; Palmer, D.R.; Sanders, D.A.
Structural investigation of myo-inositol dehydrogenase from Bacillus subtilis: implications for catalytic mechanism and inositol dehydrogenase subfamily classification
Biochem. J.
432
237-247
2010
Bacillus subtilis
Manually annotated by BRENDA team
Morinaga, T.; Ashida, H.; Yoshida, K.
Identification of two scyllo-inositol dehydrogenases in Bacillus subtilis
Microbiology
156
1538-1546
2010
Bacillus subtilis 168, Bacillus subtilis
Manually annotated by BRENDA team
Yoshida, K.; Sanbongi, A.; Murakami, A.; Suzuki, H.; Takenaka, S.; Takami, H.
Three inositol dehydrogenases involved in utilization and interconversion of inositol stereoisomers in a thermophile, Geobacillus kaustophilus HTA426
Microbiology
158
1942-1952
2012
Geobacillus kaustophilus, Geobacillus kaustophilus PS8
Manually annotated by BRENDA team