1.1.1.17: mannitol-1-phosphate 5-dehydrogenase

This is an abbreviated version, for detailed information about mannitol-1-phosphate 5-dehydrogenase, go to the full flat file.

Reaction

D-mannitol 1-phosphate
+
NAD+
=
D-fructose 6-phosphate
+
NADH
+
H+

Synonyms

BbMPD, D-mannitol-1-phosphate dehydrogenase, dehydrogenase, mannitol 1-phosphate, fructose 6-phosphate reductase, hexose reductase, long-chain mannitol-1-phosphate 5-dehydrogenase, long-chain mannitol-1-phosphate dehydrogenase, M1PDH, M1PDH1, M1PDH2, M1PDH3, mannitol 1-phosphate 5-dehydrogenase, mannitol 1-phosphate dehydrogenase, mannitol-1-phosphate dehydrogenase, MPD, MpdA, MPDH, MtlD, NAD+-dependent mannitol-1-phosphate dehydrogenase, NADH-dependent mannitol-1-phosphate 5-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.17 mannitol-1-phosphate 5-dehydrogenase

Application

Application on EC 1.1.1.17 - mannitol-1-phosphate 5-dehydrogenase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
agriculture
-
Petunia hybrida (Hook) Vilm. cv. Mitchell is transformed with an Escherichia coli gene encoding mannitol 1-phosphate dehydrogenase. The high-mannitol containing lines are more tolerant of chilling stress than the low mannitol containing transgenic lines and wild-type. In the higher mannitol lines only 0.04% to 0.06% of the total osmotic potential generated from all solutes can be attributed to mannitol, thus its action is more like that of an osmoprotectant rather than an osmoregulator. Metabolic engineering of osmoprotectant synthesis pathways can be used to improve stress tolerance in horticultural crops
pharmacology
-
inhibition of AfM1PDH might be a useful target for therapy of Aspergillus fumigatus infections
synthesis