1.1.1.17: mannitol-1-phosphate 5-dehydrogenase

This is an abbreviated version, for detailed information about mannitol-1-phosphate 5-dehydrogenase, go to the full flat file.

Reaction

D-mannitol 1-phosphate
+
NAD+
=
D-fructose 6-phosphate
+
NADH
+
H+

Synonyms

BbMPD, D-mannitol-1-phosphate dehydrogenase, dehydrogenase, mannitol 1-phosphate, EsM1PDH1, EsM1PDH2, EsM1PDH3, fructose 6-phosphate reductase, hexose reductase, long-chain mannitol-1-phosphate 5-dehydrogenase, long-chain mannitol-1-phosphate dehydrogenase, M1PDH, M1PDH1, M1PDH2, M1PDH3, mannitol 1-phosphate 5-dehydrogenase, mannitol 1-phosphate dehydrogenase, mannitol-1-phosphate dehydrogenase, MPD, MpdA, MPDH, MPDH1, MPDH2, MPDH3, Mtl-1-P dehydrogenase, MtlD, NAD+-dependent mannitol-1-phosphate dehydrogenase, NADH-dependent mannitol-1-phosphate 5-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.17 mannitol-1-phosphate 5-dehydrogenase

Cloned

Cloned on EC 1.1.1.17 - mannitol-1-phosphate 5-dehydrogenase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
enhanced tolerance to salt stress in transgenic loblolly pine simultaneously expressing two genes encoding mannitol-1-phosphate dehydrogenase and glucitol-6-phosphate dehydrogenase
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expression in Escherichia coli
expression in transgenic Oryza sativa plants, basmati indica rice, using the Agrobacterium tumefaciens transfection and DNA integration method, leading to increased tolerance to salinity and drought in the transgenic plants compared to wild-type plants by accumulation of mannitol, overview
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gene BbMPD, DNA and amino acid sequence determination and analysis, phylogenetic tree
gene EsM1PDH2 is located at Esi0020_0181, DNA and amino acid sequence determination and analysis, sequence comparison, real-time-PCR expression analysis, expression in Escherichia coli strain BL21(DE3); gene EsM1PDH3 is located at Esi0080_0017, DNA and amino acid sequence determination and analysis, sequence comparison, real-time-PCR expression analysis, expression in Escherichia coli strain BL21(DE3); gene EsM1PHD1 is located at Esi0017_0062, DNA and amino acid sequence determination and analysis, sequence comparison, real-time-PCR expression analysis, expression in Escherichia coli strain BL21(DE3)
D7FMJ8, D7G793, D8LI09
gene MPDH1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, expression analysis; gene MPDH1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, expression analysis, recombinant expression of His-tagged EsM1PDH1 in Escherichia coli; gene MPDH1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, expression analysis, recombinant expression of His-tagged EsM1PDH1 in Escherichia coli; gene MPDH1, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, expression analysis, recombinant expression of His-tagged EsM1PDH1 in Escherichia coli; gene MPDH2, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, expression analysis
D7FMJ8, D7G793, D8LI09
gene mtlD or ACIAD1672, DNA and amino acid sequence determination and analysis, real-time-PCR expression analysis, expression of His-tagged enzyme
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gene mtlD, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis
gene mtlD, recombinant expression in Beta vulgaris under control of a stress-inducible rd29A promoter, the transgenic plants are more resistant against stress caused by infections of fungi, e.g. Alternaria alternata, Botrytis cinerea, and Cercospora beticola. Expression profiling by semi-quantitative reverse transcription -PCR analysis shows different levels of cold-inducible expression of mtlD in independent T1 transformants in leafs and whole plants. AAccumulation of mannitol in T1 transgenic lines. Phenotypes, overview
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gene mtlD, recombinant expression of the enzyme under control of constitutive promoter CaMV35S in Arachis hypogaea cv. GG 20 via transfection and introduction with Agrobacterium tumefaciens strain LBA 4404, genetic transformation and regeneration of peanut from deembryonated cotyledons. All transgenic plants show accumulation of mannitol. Under water-deficit stress, different transgenic lines have significantly different levels of mannitol suggesting multiple mechanisms controlling the activity of the enzyme encoded by the transgene and the level of gene expression
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gene mtld1, encoded in the mannitol operon, sequence comparison, real-time PCR expression analysis, expression as His6-tagged protein in Escherichia coli strain SG13009
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heterologous expression in Escherichia coli JM109
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high level overexpression in Escherichia coli strain JM109
overexpression in Escherichia coli
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overexpression of enzyme in Lactococcus lactis, small amounts of mannitol are formed in growing cells of lactate dehydrogenase deficient or phosphofructokinase-reduced strains, while resting cells of lactate-dehydrogenase deficient strain convert 25% of glucose into mannitol
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Petunia hybrida (Hook) Vilm. cv. Mitchell is transformed with an Escherichia coli gene encoding mannitol 1-phosphate dehydrogenase. The high-mannitol containing lines are more tolerant of chilling stress than the low mannitol containing transgenic lines and wild-type. In the higher mannitol lines only 0.04% to 0.06% of the total osmotic potential generated from all solutes can be attributed to mannitol, thus its action is more like that of an osmoprotectant rather than an osmoregulator
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recombinant expression in Escherichia coli
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