1.1.1.17: mannitol-1-phosphate 5-dehydrogenase

This is an abbreviated version, for detailed information about mannitol-1-phosphate 5-dehydrogenase, go to the full flat file.

Reaction

D-mannitol 1-phosphate
+
NAD+
=
D-fructose 6-phosphate
+
NADH
+
H+

Synonyms

BbMPD, D-mannitol-1-phosphate dehydrogenase, dehydrogenase, mannitol 1-phosphate, fructose 6-phosphate reductase, hexose reductase, long-chain mannitol-1-phosphate 5-dehydrogenase, long-chain mannitol-1-phosphate dehydrogenase, M1PDH, M1PDH1, M1PDH2, M1PDH3, mannitol 1-phosphate 5-dehydrogenase, mannitol 1-phosphate dehydrogenase, mannitol-1-phosphate dehydrogenase, MPD, MpdA, MPDH, MtlD, NAD+-dependent mannitol-1-phosphate dehydrogenase, NADH-dependent mannitol-1-phosphate 5-dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.17 mannitol-1-phosphate 5-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.17 - mannitol-1-phosphate 5-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
weak inhibition
2,2'-bipyridyl
-
weak inhibition
4,7-phenanthroline
-
weak inhibition
4-hydroxymercuribenzoate
strong inhibition; strong inhibition; strong inhibition
5,5'-dithiobis-(2-nitrobenzoate)
-
complete inactivation at 0.24 mM
adenosine
-
48% inhibition of fructose 6-phosphate reduction
adenosine diphosphoribose
-
competitive inhibition with respect to NADH, noncompetitive inhibition with respect to D-fructose 6-phosphate
Ca2+
35.9% inhibition at 10 mM of the reverse reaction
cytidine
-
17% inhibition of fructose 6-phosphate reduction
D-fructose 1,6-diphosphate
-
12% inhibition of mannitol 1-phosphate oxidation
D-fructose 6-phosphate
D-glucose 6-phosphate
-
competitive inhibition with respect to D-fructose 6-phosphate, noncompetitive inhibition with respect to NADH
D-mannitol 1-phosphate
-
competitive inhibition with respect to D-fructose 6-phosphate, noncompetitive inhibition with respect to NADH
diethyldicarbonate
-
60% inhibition at 1 mM
diethyldithiocarbamate
-
95% inactivation, prevented by presence of 2-mercaptoethanol
DTT
46.0% inhibition at 10 mM of the reverse reaction
fructose-6-phosphate
-
substrate inhibition above 0.5 mM
GTP
-
11% inhibition of mannitol 1-phosphate oxidation
guanosine
-
10% inhibition of fructose 6-phosphate reduction
Li+
24.4% inhibition at 50 mM of the reverse reaction
Mg2+
31.2% inhibition at 10 mM of the reverse reaction
Mn2+
31.3% inhibition at 50 mM of the reverse reaction
N-ethylmaleimide
-
1 mM, 80% inhibition of reduction and oxidation reaction
NAD+
-
competitive inhibition with respect to NADH, noncompetitive inhibition with respect to D-fructose 6-phosphate
p-hydroxymercuribenzoate
-
0.5 mM, complete inhibition of reduction and oxidation reaction, 2-mercaptoethanol protects
phosphoenolpyruvate
-
14% inhibition of mannitol 1-phosphate oxidation
SDS
80.1% inhibition at 1 mM of the reverse reaction
thymidine
-
8% inhibition of fructose 6-phosphate reduction
uridine
-
16% inhibition of fructose 6-phosphate reduction
additional information
-