1.1.1.140: sorbitol-6-phosphate 2-dehydrogenase

This is an abbreviated version, for detailed information about sorbitol-6-phosphate 2-dehydrogenase, go to the full flat file.

Reaction

D-sorbitol 6-phosphate
+
NAD+
=
D-fructose 6-phosphate
+
NADH
+
H+

Synonyms

D-glucitol-6-phosphate dehydrogenase, D-sorbitol-6-phosphate 2-dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, dehydrogenase, D-sorbitol 6-phosphate, Glucitol-6-phosphate dehydrogenase, GutF, GutM, GutR, ketosephosphate reductase, MdS6PDH, More, operon gutFRMCBA, S6PDH, sorbitol-6-P-dehydrogenase, sorbitol-6-phosphate dehydrogenase, Stl6PDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.140 sorbitol-6-phosphate 2-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.140 - sorbitol-6-phosphate 2-dehydrogenase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-(5-((E)-[3,5-bis(methoxycarbonyl)phenyl]diazenyl)-2-hydroxyphenyl)propanoic acid
enzyme inhibition is accompanied by a decrease in total prostaglandin F2alpha
5-([5-(3-chlorophenyl)furan-2-yl]methyl)-1,3-thiazolidine-2,4-dione
-
5-phospho-D-arabinonate
-
substrate analogue inhibitor, IC50: 0.048 mM
5-phospho-D-arabinonohydroxamic acid
-
substrate analogue inhibitor, IC50: 0.040 mM
D-mannose 6-phosphate
-
potent inhibitor, IC50: 0.0075 mM
diethyl dicarbonate
-
100% inactivation
disodium 4-(5-[(Z)-(4-oxido-2-oxo-1,3-thiazol-5(2H)-ylidene)methyl]furan-2-yl)benzoate
reduces deactivated prostaglandin F2alpha metabolite production in outer root sheath keratinocyte supernatant
ethyl 3-(5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]furan-2-yl)benzoate
-
methyl 3-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)propanoate
-
N-ethylmaleimide
-
about 90% inactivation
NADH
-
high concentrations of
sorbitol 6-phosphate
-
-
additional information
-
gut genes are repressed by glucose
-