1.1.1.140: sorbitol-6-phosphate 2-dehydrogenase

This is an abbreviated version, for detailed information about sorbitol-6-phosphate 2-dehydrogenase, go to the full flat file.

Reaction

D-sorbitol 6-phosphate
+
NAD+
=
D-fructose 6-phosphate
+
NADH
+
H+

Synonyms

D-glucitol-6-phosphate dehydrogenase, D-sorbitol-6-phosphate 2-dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, dehydrogenase, D-sorbitol 6-phosphate, Glucitol-6-phosphate dehydrogenase, GutF, GutM, GutR, ketosephosphate reductase, MdS6PDH, More, operon gutFRMCBA, S6PDH, sorbitol-6-P-dehydrogenase, sorbitol-6-phosphate dehydrogenase, Stl6PDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.140 sorbitol-6-phosphate 2-dehydrogenase

Application

Application on EC 1.1.1.140 - sorbitol-6-phosphate 2-dehydrogenase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
-
constitutive expression of the two sorbitol-6-phosphate dehydrogenase genes srlD1 and srlD2 in a mutant strain deficient for both L- and D-lactate dehydrogenase activities. Both Stl6PDH enzymes are active, and high specific activity can be detected in the overexpressing strains. Using resting cells under pH control with glucose as a substrate, both Stl6PDHs are capable of rerouting the glycolytic flux from fructose-6-phosphate toward sorbitol production with a remarkably high efficiency of 61 to 65% glucose conversion