EC Number |
Protein Variants |
Reference |
---|
1.14.11.6 | D191A |
mutation abrogates the ability of JBP1 to complement JBP1 null mutants |
689246 |
1.14.11.6 | D215S |
mutant proteins fail to restore the J-level in the JBP1 null trypanosomes to wild-type levels |
689246 |
1.14.11.6 | D216N |
site-directed mutagenesis, the mutant shows reduced activity with thymine and altered substrate specificity compared to the wild-type enzyme |
745921 |
1.14.11.6 | D393A |
site-directed mutagenesis, mutation inside the catalytic domain, procyclic cells expressing mutant versions of JBP2 inside the catalytic domain |
700501 |
1.14.11.6 | D416A |
site-directed mutagenesis, cells expressing the LtJBP2 mutant exhibits a serious growth defect |
700084 |
1.14.11.6 | E122A |
site-directed mutagenesis, the mutant shows reduced activity with thymine and altered substrate specificity compared to the wild-type enzyme |
745921 |
1.14.11.6 | F292A |
site-directed mutagenesis, the mutant shows highly reduced activity compared to the wild-type enzyme |
745921 |
1.14.11.6 | H189A |
mutation abrogates the ability of JBP1 to complement JBP1 null mutants |
689246 |
1.14.11.6 | H189A/D191A |
mutation abrogates the ability of JBP1 to complement JBP1 null mutants |
689246 |
1.14.11.6 | H213S |
mutant proteins fail to restore the J-level in the JBP1 null trypanosomes to wild-type levels |
689246 |