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EC Number
Protein Variants
Commentary
Reference
3.1.1.106
D77N/D78N
hydrolysis of O-acetyl-D-ADP-ribose is abolished by these mutations
752026
3.1.1.106
N25A/D35A
inactive
751419
3.1.1.106
Y126A
inactive
751419
3.1.1.106
G100E
the mutant isoform MacroD2 lacks hydrolase and ADP-ribose-binding activities
751688
3.1.1.106
G214E
the mutant shows about 0.2% of wild type activity
751029
3.1.1.106
G270E
the mutant shows about 1% of wild type activity
751029
3.1.1.106
G124E
the mutant shows about 1.0% of wild type activity
751029
3.1.1.106
T226A
the mutant shows about 102.9% of wild type activity
751029
3.1.1.106
D122A
the mutant shows about 24.5% of wild type activity
751029
3.1.1.106
D184A
the mutant shows about 39.3% of wild type activity
751029
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