Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.106 extracted from

  • Rosenthal, F.; Feijs, K.L.; Frugier, E.; Bonalli, M.; Forst, A.H.; Imhof, R.; Winkler, H.C.; Fischer, D.; Caflisch, A.; Hassa, P.O.; Luescher, B.; Hottiger, M.O.
    Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases (2013), Nat. Struct. Mol. Biol., 20, 502-507 .
    View publication on PubMed
Search for more literature for 3.1.1.106

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
G100E the mutant isoform MacroD2 lacks hydrolase and ADP-ribose-binding activities Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O Homo sapiens
-
 ADP-D-ribose + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens A1Z1Q3
-
-
Homo sapiens Q9BQ69
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-Sepharose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
3''-O-acetyl-ADP-D-ribose + H2O
-
 Homo sapiens ADP-D-ribose + acetate
-
 ?
additional information isoform MacroD1 is completely inactive toward poly-ADP-D-ribose synthesized by ADP-ribosyltransferase diphtheria toxin-like 1 in the presence of high NAD+ concentrations Homo sapiens ?
-
 ?
additional information isoform MacroD2 is a mono-ADP-ribosylhydrolase specific for acidic residues of aspartates and glutamates Homo sapiens ?
-
 ?
additional information isoform MacroD2 is completely inactive toward poly-ADP-D-ribose synthesized by ADP-ribosyltransferase diphtheria toxin-like 1 in the presence of high NAD+ concentrations. MacroD2 does not remove ADP-D-ribose modifications generated by the arginine-specific enzyme CDTa or TccC3 Homo sapiens ?
-
 ?
[ARTD10 protein]-ADP-D-ribose + H2O
-
 Homo sapiens [ARTD10 protein] + ADP-D-ribose
-
 ?
[glycogen synthase kinase 3beta]-ADP-D-ribose + H2O
-
 Homo sapiens [glycogen synthase kinase 3beta] + ADP-D-ribose
-
 ?

Synonyms

Synonyms Comment Organism
C6orf130
-
 Homo sapiens
MACROD1
-
 Homo sapiens
MacroD2
-
 Homo sapiens
mono-ADP-ribosylhydrolase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function isoform MacroD2 regulates GSK3beta function Homo sapiens