BRENDA - Enzyme Database
show all sequences of 3.1.1.106

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases

Chen, D.; Vollmar, M.; Rossi, M.N.; Phillips, C.; Kraehenbuehl, R.; Slade, D.; Mehrotra, P.V.; von Delft, F.; Crosthwaite, S.K.; Gileadi, O.; Denu, J.M.; Ahel, I.; J. Biol. Chem. 286, 13261-13271 (2011)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
enzyme isoform MacroD1 is expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells
Homo sapiens
Crystallization (Commentary)
Crystallization
Organism
isoform MacroD1, sitting drop vapor diffusion method, using 0.2 M (NH4)2SO4, 0.1 M HEPES pH 7.5, 25% (w/v) PEG 3350 at 4°C
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
C199A
the mutant shows about 90.4% of wild type activity
Homo sapiens
D122A
the mutant shows about 24.5% of wild type activity
Staphylococcus aureus
D160A
the mutant shows about 57% of wild type activity
Homo sapiens
D167A
the mutant shows about 68.7% of wild type activity
Homo sapiens
D184A
the mutant shows about 39.3% of wild type activity
Homo sapiens
G124E
the mutant shows about 1.0% of wild type activity
Escherichia coli
G214E
the mutant shows about 0.2% of wild type activity
Staphylococcus aureus
G270E
the mutant shows about 1% of wild type activity
Homo sapiens
H188A
the mutant shows about 57.6% of wild type activity
Homo sapiens
N171A
the mutant shows about 41.3% of wild type activity
Homo sapiens
N174A
the mutant shows about 57.3% of wild type activity
Homo sapiens
N174A/D184A
the mutant shows about 7% of wild type activity
Homo sapiens
S176A
the mutant shows about 98.4% of wild type activity
Homo sapiens
S268A
the mutant shows about 77% of wild type activity
Homo sapiens
T226A
the mutant shows about 102.9% of wild type activity
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
ADP-D-ribose
-
Escherichia coli
ADP-D-ribose
;
Homo sapiens
ADP-D-ribose
-
Staphylococcus aureus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.107
-
O-acetyl-ADP-D-ribose
isoform MacroD2, at pH 7.3 and 23°C
Homo sapiens
0.27
-
O-acetyl-ADP-D-ribose
at pH 7.3 and 23°C
Escherichia coli
0.375
-
O-acetyl-ADP-D-ribose
isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
2
-
O-acetyl-ADP-D-ribose
at pH 7.3 and 23°C
Staphylococcus aureus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
Staphylococcus aureus
-
ADP-D-ribose + acetate
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
Escherichia coli
-
ADP-D-ribose + acetate
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Staphylococcus aureus
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Escherichia coli
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Escherichia coli
-
-
-
Homo sapiens
A1Z1Q3
-
-
Homo sapiens
Q9BQ69
-
-
Staphylococcus aureus
-
-
-
Purification (Commentary)
Commentary
Organism
HisTrap column chromatography and Superdex 75 gel filtration
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
HeLa cell
;
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
-
751029
Staphylococcus aureus
ADP-D-ribose + acetate
-
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
-
751029
Escherichia coli
ADP-D-ribose + acetate
-
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
-
751029
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751029
Staphylococcus aureus
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751029
Escherichia coli
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751029
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
O-acetyl-ADP-D-ribose + H2O
-
751029
Staphylococcus aureus
ADP-D-ribose + acetate
-
-
-
?
O-acetyl-ADP-D-ribose + H2O
-
751029
Escherichia coli
ADP-D-ribose + acetate
-
-
-
?
O-acetyl-ADP-D-ribose + H2O
-
751029
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.002
-
O-acetyl-ADP-D-ribose
mutant G270E of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.005
-
O-acetyl-ADP-D-ribose
mutant G124E, at pH 7.3 and 23°C
Escherichia coli
0.007
-
O-acetyl-ADP-D-ribose
mutant G214E, at pH 7.3 and 23°C
Staphylococcus aureus
0.014
-
O-acetyl-ADP-D-ribose
mutant N174A/D184A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.078
-
O-acetyl-ADP-D-ribose
mutant D184A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.082
-
O-acetyl-ADP-D-ribose
mutant N171A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.113
-
O-acetyl-ADP-D-ribose
mutant N174A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.114
-
O-acetyl-ADP-D-ribose
mutant D160A of isoform MacroD1, at pH 7.3 and 23°C; mutant H188A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.12
-
O-acetyl-ADP-D-ribose
isoform MacroD2, at pH 7.3 and 23°C
Homo sapiens
0.136
-
O-acetyl-ADP-D-ribose
mutant D167A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.153
-
O-acetyl-ADP-D-ribose
mutant S268A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.179
-
O-acetyl-ADP-D-ribose
mutant C199A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.195
-
O-acetyl-ADP-D-ribose
mutant S176A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.198
-
O-acetyl-ADP-D-ribose
isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.204
-
O-acetyl-ADP-D-ribose
mutant T226A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.48
-
O-acetyl-ADP-D-ribose
wild type enzyme, at pH 7.3 and 23°C
Escherichia coli
0.679
-
O-acetyl-ADP-D-ribose
mutant D122A, at pH 7.3 and 23°C
Staphylococcus aureus
2.77
-
O-acetyl-ADP-D-ribose
wild type enzyme, at pH 7.3 and 23°C
Staphylococcus aureus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.145
-
ADP-D-ribose
isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
enzyme isoform MacroD1 is expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells
Homo sapiens
Crystallization (Commentary) (protein specific)
Crystallization
Organism
isoform MacroD1, sitting drop vapor diffusion method, using 0.2 M (NH4)2SO4, 0.1 M HEPES pH 7.5, 25% (w/v) PEG 3350 at 4°C
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
C199A
the mutant shows about 90.4% of wild type activity
Homo sapiens
D122A
the mutant shows about 24.5% of wild type activity
Staphylococcus aureus
D160A
the mutant shows about 57% of wild type activity
Homo sapiens
D167A
the mutant shows about 68.7% of wild type activity
Homo sapiens
D184A
the mutant shows about 39.3% of wild type activity
Homo sapiens
G124E
the mutant shows about 1.0% of wild type activity
Escherichia coli
G214E
the mutant shows about 0.2% of wild type activity
Staphylococcus aureus
G270E
the mutant shows about 1% of wild type activity
Homo sapiens
H188A
the mutant shows about 57.6% of wild type activity
Homo sapiens
N171A
the mutant shows about 41.3% of wild type activity
Homo sapiens
N174A
the mutant shows about 57.3% of wild type activity
Homo sapiens
N174A/D184A
the mutant shows about 7% of wild type activity
Homo sapiens
S176A
the mutant shows about 98.4% of wild type activity
Homo sapiens
S268A
the mutant shows about 77% of wild type activity
Homo sapiens
T226A
the mutant shows about 102.9% of wild type activity
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ADP-D-ribose
-
Escherichia coli
ADP-D-ribose
-
Homo sapiens
ADP-D-ribose
-
Staphylococcus aureus
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.145
-
ADP-D-ribose
isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.107
-
O-acetyl-ADP-D-ribose
isoform MacroD2, at pH 7.3 and 23°C
Homo sapiens
0.27
-
O-acetyl-ADP-D-ribose
at pH 7.3 and 23°C
Escherichia coli
0.375
-
O-acetyl-ADP-D-ribose
isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
2
-
O-acetyl-ADP-D-ribose
at pH 7.3 and 23°C
Staphylococcus aureus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
Staphylococcus aureus
-
ADP-D-ribose + acetate
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
Escherichia coli
-
ADP-D-ribose + acetate
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Staphylococcus aureus
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Escherichia coli
-
ADP-D-ribose + acetate
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
Homo sapiens
-
ADP-D-ribose + acetate
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
HisTrap column chromatography and Superdex 75 gel filtration
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
HeLa cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2''-O-acetyl-ADP-D-ribose + H2O
-
751029
Staphylococcus aureus
ADP-D-ribose + acetate
-
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
-
751029
Escherichia coli
ADP-D-ribose + acetate
-
-
-
?
2''-O-acetyl-ADP-D-ribose + H2O
-
751029
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751029
Staphylococcus aureus
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751029
Escherichia coli
ADP-D-ribose + acetate
-
-
-
?
3''-O-acetyl-ADP-D-ribose + H2O
-
751029
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
O-acetyl-ADP-D-ribose + H2O
-
751029
Staphylococcus aureus
ADP-D-ribose + acetate
-
-
-
?
O-acetyl-ADP-D-ribose + H2O
-
751029
Escherichia coli
ADP-D-ribose + acetate
-
-
-
?
O-acetyl-ADP-D-ribose + H2O
-
751029
Homo sapiens
ADP-D-ribose + acetate
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.002
-
O-acetyl-ADP-D-ribose
mutant G270E of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.005
-
O-acetyl-ADP-D-ribose
mutant G124E, at pH 7.3 and 23°C
Escherichia coli
0.007
-
O-acetyl-ADP-D-ribose
mutant G214E, at pH 7.3 and 23°C
Staphylococcus aureus
0.014
-
O-acetyl-ADP-D-ribose
mutant N174A/D184A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.078
-
O-acetyl-ADP-D-ribose
mutant D184A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.082
-
O-acetyl-ADP-D-ribose
mutant N171A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.113
-
O-acetyl-ADP-D-ribose
mutant N174A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.114
-
O-acetyl-ADP-D-ribose
mutant D160A of isoform MacroD1, at pH 7.3 and 23°C; mutant H188A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.12
-
O-acetyl-ADP-D-ribose
isoform MacroD2, at pH 7.3 and 23°C
Homo sapiens
0.136
-
O-acetyl-ADP-D-ribose
mutant D167A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.153
-
O-acetyl-ADP-D-ribose
mutant S268A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.179
-
O-acetyl-ADP-D-ribose
mutant C199A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.195
-
O-acetyl-ADP-D-ribose
mutant S176A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.198
-
O-acetyl-ADP-D-ribose
isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.204
-
O-acetyl-ADP-D-ribose
mutant T226A of isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
0.48
-
O-acetyl-ADP-D-ribose
wild type enzyme, at pH 7.3 and 23°C
Escherichia coli
0.679
-
O-acetyl-ADP-D-ribose
mutant D122A, at pH 7.3 and 23°C
Staphylococcus aureus
2.77
-
O-acetyl-ADP-D-ribose
wild type enzyme, at pH 7.3 and 23°C
Staphylococcus aureus
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.533
-
O-acetyl-ADP-D-ribose
isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
1.1
-
O-acetyl-ADP-D-ribose
isoform MacroD2, at pH 7.3 and 23°C
Homo sapiens
1.78
-
O-acetyl-ADP-D-ribose
at pH 7.3 and 23°C
Escherichia coli
1.84
-
O-acetyl-ADP-D-ribose
at pH 7.3 and 23°C
Staphylococcus aureus
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
0.533
-
O-acetyl-ADP-D-ribose
isoform MacroD1, at pH 7.3 and 23°C
Homo sapiens
1.1
-
O-acetyl-ADP-D-ribose
isoform MacroD2, at pH 7.3 and 23°C
Homo sapiens
1.78
-
O-acetyl-ADP-D-ribose
at pH 7.3 and 23°C
Escherichia coli
1.84
-
O-acetyl-ADP-D-ribose
at pH 7.3 and 23°C
Staphylococcus aureus
Other publictions for EC 3.1.1.106
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
750645
Agnew
MacroD1 is a promiscuous ADP- ...
Homo sapiens, Mus musculus
Front. Microbiol.
9
20
2018
-
-
-
-
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-
-
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2
-
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4
-
4
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5
-
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8
2
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-
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2
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4
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5
-
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8
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
752262
Haikarainen
Development of an inhibitor s ...
Homo sapiens
SLAS Discov.
23
255-263
2018
-
-
1
-
-
-
5
-
-
-
-
3
-
2
-
-
1
-
-
-
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-
3
-
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-
-
-
-
-
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-
4
-
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1
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4
5
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3
-
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1
-
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-
3
-
-
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-
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-
-
-
-
-
-
-
-
752189
Haikarainen
Proximal ADP-ribose hydrolysi ...
Trypanosoma brucei gambiense, Trypanosoma cruzi, Trypanosoma cruzi CL Brener
Sci. Rep.
6
24213
2016
-
-
2
2
-
-
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-
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-
-
9
-
8
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-
2
-
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9
-
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2
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2
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9
-
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2
-
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9
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
751419
Zhang
Structural insights into the ...
Escherichia coli
J. Struct. Biol.
192
478-486
2015
-
-
1
1
4
-
-
3
-
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-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
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3
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1
-
1
4
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3
-
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-
1
-
-
-
1
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2
-
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3
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3
3
749471
Hirsch
Transition-state analysis of ...
Homo sapiens
ACS Chem. Biol.
9
2255-2262
2014
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-
1
-
-
-
-
2
-
-
-
2
-
2
-
-
-
-
-
-
-
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2
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-
-
-
2
-
-
-
-
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-
-
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-
1
-
-
-
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-
-
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2
-
-
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2
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-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
751688
Rosenthal
Macrodomain-containing protei ...
Homo sapiens
Nat. Struct. Mol. Biol.
20
502-507
2013
-
-
1
-
1
-
-
-
-
-
-
6
-
5
-
-
1
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
3
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
751029
Chen
Identification of macrodomain ...
Escherichia coli, Homo sapiens, Staphylococcus aureus
J. Biol. Chem.
286
13261-13271
2011
-
-
1
1
15
-
3
4
-
-
-
8
-
8
-
-
1
-
-
1
-
-
12
-
-
-
-
18
-
-
-
-
1
-
-
-
-
1
-
1
15
-
-
4
1
4
-
-
-
8
-
-
-
1
-
2
-
-
12
-
-
-
-
18
-
-
-
-
-
-
-
-
4
4
751030
Kasamatsu
Hydrolysis of O-acetyl-ADP-ri ...
Homo sapiens
J. Biol. Chem.
286
21110-21117
2011
-
-
-
-
-
-
4
1
-
1
-
1
-
1
-
-
-
-
-
-
-
-
6
1
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
3
4
-
1
-
1
-
1
-
-
-
-
-
-
-
-
6
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
752026
Ono
The 39-kDa poly(ADP-ribose) g ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
16687-16691
2006
1
-
-
-
3
-
2
-
-
1
-
2
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
2
1
-
-
1
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
751012
Rafty
-
Analysis of O-acetyl-ADP-ribo ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
277
47114-47122
2002
-
-
-
-
-
-
-
-
2
-
-
4
-
2
-
-
-
-
-
3
-
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4
-
-
-
-
-
-
-
-
-
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2
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4
-
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3
-
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4
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