Data extracted from this reference:
Activating Compound
additional information
not affected by dithiothreitol
Homo sapiens
Engineering
D77N/D78N
hydrolysis of O-acetyl-D-ADP-ribose is abolished by these mutations
Homo sapiens
E238Q/E239Q
the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose
Homo sapiens
E261Q/E262Q
the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose
Homo sapiens
Inhibitors
ADP-D-ribose
competitive inhibitor
Homo sapiens
additional information
D-ribose 5-phosphate, AMP, ADP and beta-NAD have relatively little inhibitory effect on the enzyme activity
Homo sapiens
Metals/Ions
Mg2+
dependent on Mg2+. 1 mM is used in assay conditions
Homo sapiens
Natural Substrates/ Products (Substrates)
O-acetyl-ADP-D-ribose + H2O
Homo sapiens
ADP-D-ribose + acetate
?
poly(ADP-D-ribose) + H2O
Homo sapiens
?
?
Organism
Substrates and Products (Substrate)
O-acetyl-ADP-D-ribose + H2O
752026
Homo sapiens
ADP-D-ribose + acetate
?
poly(ADP-D-ribose) + H2O
752026
Homo sapiens
?
?
Subunits
?
x * 39000, SDS-PAGE
Homo sapiens
Synonyms
O-acetyl-ADP-ribose hydrolase
Homo sapiens
poly(ADP-ribose) glycohydrolase
Homo sapiens
Ki Value [mM]
0.002
ADP-D-ribose
at pH 7.0 and 30°C
Homo sapiens
Activating Compound (protein specific)
additional information
not affected by dithiothreitol
Homo sapiens
Engineering (protein specific)
D77N/D78N
hydrolysis of O-acetyl-D-ADP-ribose is abolished by these mutations
Homo sapiens
E238Q/E239Q
the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose
Homo sapiens
E261Q/E262Q
the mutant shows wild type hydrolytic activity with O-acetyl-D-ADP-ribose
Homo sapiens
Inhibitors (protein specific)
ADP-D-ribose
competitive inhibitor
Homo sapiens
additional information
D-ribose 5-phosphate, AMP, ADP and beta-NAD have relatively little inhibitory effect on the enzyme activity
Homo sapiens
Ki Value [mM] (protein specific)
0.002
ADP-D-ribose
at pH 7.0 and 30°C
Homo sapiens
Metals/Ions (protein specific)
Mg2+
dependent on Mg2+. 1 mM is used in assay conditions
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
O-acetyl-ADP-D-ribose + H2O
Homo sapiens
ADP-D-ribose + acetate
?
poly(ADP-D-ribose) + H2O
Homo sapiens
?
?
Substrates and Products (Substrate) (protein specific)
O-acetyl-ADP-D-ribose + H2O
752026
Homo sapiens
ADP-D-ribose + acetate
?
poly(ADP-D-ribose) + H2O
752026
Homo sapiens
?
?
Subunits (protein specific)
?
x * 39000, SDS-PAGE
Homo sapiens
Other publictions for EC 3.1.1.106
750645
Agnew
MacroD1 is a promiscuous ADP- ...
Homo sapiens, Mus musculus
Front. Microbiol.
9
20
2018
-
-
-
-
-
-
-
-
2
-
-
4
-
4
-
-
-
-
-
5
-
-
8
2
4
-
-
-
-
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-
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-
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2
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4
-
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5
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8
2
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-
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-
-
-
752262
Haikarainen
Development of an inhibitor s ...
Homo sapiens
SLAS Discov.
23
255-263
2018
-
-
1
-
-
-
5
-
-
-
-
3
-
2
-
-
1
-
-
-
-
-
3
-
1
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4
-
-
1
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4
5
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3
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1
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3
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-
-
-
752189
Haikarainen
Proximal ADP-ribose hydrolysi ...
Trypanosoma brucei gambiense, Trypanosoma cruzi, Trypanosoma cruzi CL Brener
Sci. Rep.
6
24213
2016
-
-
2
2
-
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-
-
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-
9
-
8
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-
2
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9
-
6
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2
-
2
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9
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2
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9
-
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-
751419
Zhang
Structural insights into the ...
Escherichia coli
J. Struct. Biol.
192
478-486
2015
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-
1
1
4
-
-
3
-
-
-
1
-
1
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-
1
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2
-
2
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3
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1
-
1
4
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3
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1
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1
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2
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-
3
-
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-
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3
3
749471
Hirsch
Transition-state analysis of ...
Homo sapiens
ACS Chem. Biol.
9
2255-2262
2014
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-
1
-
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2
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2
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2
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2
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2
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2
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1
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2
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2
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2
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-
2
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2
2
751688
Rosenthal
Macrodomain-containing protei ...
Homo sapiens
Nat. Struct. Mol. Biol.
20
502-507
2013
-
-
1
-
1
-
-
-
-
-
-
6
-
5
-
-
1
-
-
-
-
-
13
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
6
-
-
-
3
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
751029
Chen
Identification of macrodomain ...
Escherichia coli, Homo sapiens, Staphylococcus aureus
J. Biol. Chem.
286
13261-13271
2011
-
-
1
1
15
-
3
4
-
-
-
8
-
8
-
-
1
-
-
1
-
-
12
-
13
-
-
-
18
-
-
-
-
1
-
-
-
-
1
-
1
15
-
-
4
1
4
-
-
-
8
-
-
-
1
-
2
-
-
12
-
-
-
-
18
-
-
-
-
-
-
-
-
4
4
751030
Kasamatsu
Hydrolysis of O-acetyl-ADP-ri ...
Homo sapiens
J. Biol. Chem.
286
21110-21117
2011
-
-
-
-
-
-
4
1
-
1
-
1
-
1
-
-
-
-
-
-
-
-
6
1
3
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
3
4
-
1
-
1
-
1
-
-
-
-
-
-
-
-
6
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
752026
Ono
The 39-kDa poly(ADP-ribose) g ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
103
16687-16691
2006
1
-
-
-
3
-
2
-
-
1
-
2
-
1
-
-
-
-
-
-
-
-
2
1
3
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
3
-
-
2
1
-
-
1
-
2
-
-
-
-
-
-
-
-
2
1
-
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-
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-
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-
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-
751012
Rafty
-
Analysis of O-acetyl-ADP-ribo ...
Homo sapiens, Saccharomyces cerevisiae
J. Biol. Chem.
277
47114-47122
2002
-
-
-
-
-
-
-
-
2
-
-
4
-
2
-
-
-
-
-
3
-
-
4
-
2
-
-
-
-
-
-
-
-
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-
-
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2
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4
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3
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4
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-