EC Number   |
Protein Variants |
Reference |
|---|
   3.4.17.23 | K417T/E484K/N501Y |
variant possesses both enhanced affinity and antibody resistance |
763365 |
| 3.4.17.23 | K481Q |
angiotensin I cleavage activity is 21% of wild-type activity, angiotensin II cleavage activity is 71.8% of wild-type activity |
692319 |
| 3.4.17.23 | K68E |
variant exhibits lower binding to SARS-CoV-2 S protein |
762786 |
| 3.4.17.23 | L584A |
the point mutation in the ACE2 ectodomain markedly attenuates shedding. The resultant ACE2-L584A mutant trafficks to the cell membrane and facilitates SARS-CoV entry into target cells |
707074 |
| 3.4.17.23 | L595V |
non-synonymous single nucleotide polymorphism |
765112 |
| 3.4.17.23 | L731F |
deleterious missense variant |
762786 |
| 3.4.17.23 | L79I |
mutation increases binding of SARS-CoV-2 spike protein |
765703 |
| 3.4.17.23 | M62V |
variant exhibits lower binding to SARS-CoV-2 S protein |
762786 |
| 3.4.17.23 | more |
ACE2 overexpression leads to markedly increased myocyte volume, assessed in primary rabbit myocytes |
708684 |
| 3.4.17.23 | more |
construction of a soluble truncated mutant enzyme lacking the transmembrane and cytosolic domains |
657967, 659147 |
