EC Number   |
Protein Variants |
Reference |
|---|
   3.4.17.23 | S692P |
deleterious missense variant |
762786 |
| 3.4.17.23 | T27A |
the variant in the binding region increases disease susceptibility towards SARS-CoV-2 |
762786 |
| 3.4.17.23 | T92I |
the variant in the binding region increases disease susceptibility towards SARS-CoV-2 |
762786 |
| 3.4.17.23 | V581A |
the mutation in the ectodomain has no effect on sACE2 release |
707074 |
| 3.4.17.23 | V604A |
the mutation in the ectodomain has no effect on sACE2 release |
707074 |
| 3.4.17.23 | W271A |
angiotensin I cleavage activity is 5.3% of wild-type activity, angiotensin II cleavage activity is 0.9% of wild-type activity. Lacks any significant chloride sensitivity with the substrate angiotensin I |
692319 |
| 3.4.17.23 | W459C |
non-synonymous single nucleotide polymorphism |
765112 |
| 3.4.17.23 | Y252N |
non-synonymous single nucleotide polymorphism |
765112 |
| 3.4.17.23 | Y50F |
variant exhibits lower binding to SARS-CoV-2 S protein |
762786 |
| 3.4.17.23 | Y83H |
variant exhibits lower binding to SARS-CoV-2 S protein |
762786 |
