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Literature summary for 3.4.17.23 extracted from

  • AlGhamdi, N.A.; Alsuwat, H.S.; Borgio, J.F.; AbdulAzeez, S.
    Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection in silico approaches (2022), J. Biomol. Struct. Dyn., 40, 2635-2646 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine analysis of variations in SARS-CoV-2 spike protein and hACE2 receptor protein and their interaction in the infection scale. Interactions of hACE2 variants with SARS-CoV-2 variants are very strong for G726R-G476S, R768W-V367F, Y252N-V483A, Y252N-V367F, G726R-V367F, N720D-V367F and N720DF486L, and weak for P263S-S383C, RBD-H378R, G726R-A348T Homo sapiens

Protein Variants

Protein Variants Comment Organism
E329G variant shows a strong binding affinity with SARS-CoV-2 spike protein variants with very strong E329G-V483A, E329G-G476S, strong E329G-A419S, E329G-A348T and moderate E329G-S383C,E329G-F486L interaction Homo sapiens
E37K non-synonymous single nucleotide polymorphism Homo sapiens
G726R non-synonymous single nucleotide polymorphism Homo sapiens
H378R non-synonymous single nucleotide polymorphism Homo sapiens
L595V non-synonymous single nucleotide polymorphism Homo sapiens
N720D non-synonymous single nucleotide polymorphism Homo sapiens
P263S non-synonymous single nucleotide polymorphism Homo sapiens
P284S non-synonymous single nucleotide polymorphism Homo sapiens
R768W non-synonymous single nucleotide polymorphism Homo sapiens
S563L non-synonymous single nucleotide polymorphism Homo sapiens
W459C non-synonymous single nucleotide polymorphism Homo sapiens
Y252N non-synonymous single nucleotide polymorphism Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BYF1
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