EC Number |
Protein Variants |
Reference |
---|
3.4.17.23 | H378R |
non-synonymous single nucleotide polymorphism |
765112 |
3.4.17.23 | H378R |
the variant in the binding region increases disease susceptibility towards SARS-CoV-2 |
762786 |
3.4.17.23 | H505A |
1.5% of wild-type activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl as substrate |
668550 |
3.4.17.23 | H505L |
no activity with (7-methoxycoumarin-4-yl)acetyl-APK-2,4-dinitrophenyl |
668550 |
3.4.17.23 | I21V |
the variant in the binding region increases disease susceptibility towards SARS-CoV-2 |
762786 |
3.4.17.23 | I468V |
deleterious missense variant |
762786 |
3.4.17.23 | K26R |
missense variant, mutation affect protein structure and stability |
762786 |
3.4.17.23 | K26R |
the variant in the binding region increases disease susceptibility towards SARS-CoV-2 |
762786 |
3.4.17.23 | K31R |
variant exhibits lower binding to SARS-CoV-2 S protein |
762786 |
3.4.17.23 | K341R |
deleterious missense variant |
762786 |