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<< < Results 31 - 40 of 42 > >>
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90more the enzyme transfected 7721 hepatocarcinoma cell line is more susceptible to cycloheximide-induced apoptosis than the wild-type cells, cells show increased enzyme activity and expression of Galbeta1,4GlcNAc groups on the cell surface 659925
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90Y289L/C342T site-directed mutagenesis, the mutant is able to transfer GalNAc from the sugar donor UDP-GalNAc to the acceptor, GlcNAc, with efficiency as good as that of galactose from UDP-Gal, in contrast to the wild-type enzyme, mutant substrate specificity with different donor substrate and oligosaccharides as acceptor substrates, mass spectrometry product analysis, overview, the C342T mutation does not alter enzyme activity, but increases the enzyme stability at room temperature 672454
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90I285Y site-directed mutagenesis, the mutation converts the betaGALNAcT1 enzyme into an efficient beta4Gal-T1, the N-acetylgalactosaminyltransferase activity is reduced by nearly 1000fold, while the galactosyltransferase activity is enhanced by 80fold 675421
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90more decreasing the expression of beta1,4GalT II using RNA interference inhibits p53-mediated HeLa cell apoptosis induced by adriamycin 687455
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90DELTA1-70 crystallization of a refolded Drosophila Cd7 protein coding the catalytic domain (Cd7) sequence (residues 71-322) is not successful 719863
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90DELTA1-70/DELTA312-322 a DNA fragment bearing the Cd7 catalytic domain and C-terminal 11-amino acid deletion (Cd7DELTAC) sequence (residues 71-311) shows no difference in catalytic activity or folding but crystalization is not possible 719863
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90more a construct bearing the N-terminal peptides from bovine Cd1 (residues 143–175 (P1)) fused with peptide with the Cd7DELTAC protein (last 11 amino acids deleted) shows no impact on the catalytic activity nor the folding efficiency. This construct is used for successful crystallization 719863
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90Y268G/W294G inactive 757209
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90D315A the mutant shows about 90% of wild type activity 758173
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.90H343A the mutant shows about 3% of wild type activity 758173
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