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Literature summary for 2.4.1.90 extracted from
- Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates (2007), J. Mol. Biol., 365, 570-576.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| I285Y | site-directed mutagenesis, the mutation converts the betaGALNAcT1 enzyme into an efficient beta4Gal-T1, the N-acetylgalactosaminyltransferase activity is reduced by nearly 1000fold, while the galactosyltransferase activity is enhanced by 80fold | Drosophila melanogaster |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-lactalbumin | inhibits the GalNAc transferase activity of the enzyme | Drosophila melanogaster |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | required | Drosophila melanogaster |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Drosophila melanogaster | the preexisting alpha-lactalbumin-binding site iss utilized during mammalian evolution to synthesize lactose in the mammary gland during lactation | ? | - |
? | |
| UDP-galactose + N-acetylglucosamine | Drosophila melanogaster | - |
UDP + N-acetyllactosamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the preexisting alpha-lactalbumin-binding site iss utilized during mammalian evolution to synthesize lactose in the mammary gland during lactation | Drosophila melanogaster | ? | - |
? | |
| UDP-galactose + N-acetylglucosamine | - |
Drosophila melanogaster | UDP + N-acetyllactosamine | - |
? | |
| UDP-galactose + N-acetylglucosamine | wild-type enzyme, residue I285 alone is responsible for determination of enzyme substrate specificity, overview, active site structure, overview | Drosophila melanogaster | UDP + N-acetyllactosamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta1,4-galactosyltransferase-1 | - |
Drosophila melanogaster |
| betaGALT1 | - |
Drosophila melanogaster |
| GalT1 | - |
Drosophila melanogaster |
| More | cf. EC 2.4.1.38 | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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