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Literature summary for 2.4.1.90 extracted from

  • Cui, C.; Chen, X.; Liu, Y.; Cao, B.; Xing, Y.; Liu, C.; Yang, F.; Li, Y.; Yang, T.; Hua, L.; Tian, M.; Wei, Y.; Gong, Y.; Jiang, J.
    beta1,4-Galactosyltransferase V activates Notch1 signaling in glioma stem-like cells and promotes their transdifferentiation into endothelial cells (2018), J. Biol. Chem., 293, 2219-2230 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
Y268G/W294G inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-galactose + N-acetyl-D-glucosamine Homo sapiens
-
UDP + N-acetyllactosamine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
GBM cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-galactose + N-acetyl-D-glucosamine
-
Homo sapiens UDP + N-acetyllactosamine
-
?

Subunits

Subunits Comment Organism
? x * 50000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
beta1,4-galactosyltransferase V
-
Homo sapiens
beta1,4GalTV
-
Homo sapiens

General Information

General Information Comment Organism
malfunction short hairpin RNA-mediated enzyme knockdown inhibits the tumorigenesis of glioma stem-like cells and reduces their transdifferentiation into endothelial cells Homo sapiens
physiological function the enzyme promotes glioma cell growth. Enzyme overexpression increases glioma stem-like cell transdifferentiation into endothelial cells. The enzyme stimulates transdifferentiation of glioma stem-like cells into endothelial cells by activating Notch1 signaling Homo sapiens