EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   2.7.11.23 | ATP + GST-tagged yCTD fusion protein |
hCDK13 purified from nuclear extracts displays CTD kinase activity in vitro with recombinant GST-tagged yeast CTD fusion proteins as substrate, hyperphosphorylation of the CTD by hCDK13 kinase |
Homo sapiens |
? |
- |
? |
| 2.7.11.23 | ATP + histone H3 |
Ctk1 is essential for H3K36 methylation, also regulates H3K4 methylation |
Saccharomyces cerevisiae |
? |
- |
? |
| 2.7.11.23 | ATP + histone H3 |
Ctk1 is essential for H3K36 methylation, also regulates H3K4 methylation |
Saccharomyces cerevisiae BY4741 |
? |
- |
? |
| 2.7.11.23 | ATP + holo-RNA polymerase II |
C-terminal domain phosphorylation by the serine 5-specific TFIIH complex, its kinase module TFIIK or by the C-terminal domain serine 2-specific kinase CTDK1 |
Saccharomyces cerevisiae |
? |
- |
? |
| 2.7.11.23 | ATP + RNA polymerase II |
- |
Saccharomyces cerevisiae |
? |
- |
? |
| 2.7.11.23 | ATP + RNA polymerase II |
both cdk7 and cdk9 are responsible for phosphorylation at the C-terminal domain |
Homo sapiens |
? |
- |
? |
| 2.7.11.23 | ATP + RNA polymerase II |
C-terminal domain phosphorylation is required for co-transcriptional splicing |
Xenopus laevis |
? |
- |
? |
| 2.7.11.23 | ATP + RNA polymerase II |
CDK9 phosphorylates the C-terminal domain on serine 5 |
Homo sapiens |
? |
- |
? |
| 2.7.11.23 | ATP + RNA polymerase II |
phosphorylation on C-terminal domain |
Drosophila melanogaster |
? |
- |
? |
| 2.7.11.23 | ATP + RNA polymerase II |
TFIIH and mediator phosphorylate at C-terminal domain at Ser 5, Ser5 phosphorylation by the yeast Cdk7 (Kin28) subunit of TFIIH is required for recruitment of capping enzyme to the promoter region, P-TEFb phosphorylates at Ser 2 |
Saccharomyces cerevisiae |
? |
- |
? |
