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Information on EC 2.7.11.23 - [RNA-polymerase]-subunit kinase
for references in articles please use BRENDA:EC2.7.11.23
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EC Tree 2 Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.23 [RNA-polymerase]-subunit kinase
IUBMB Comments
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
- 2.7.11.23
- cyclin
- strand
- chromatin
- histone
-
non-homologous
-
cyclin-dependent
-
end-joining
-
radiosensitivity
-
transactivation
- helicase
-
checkpoint
-
radiation-induced
- pigmentosum
- xeroderma
- ataxia
- telangiectasia
- h2ax
-
dna-damaging
- tfiie
- wortmannin
-
preinitiation
- ataxia-telangiectasia
-
rejoin
- cak
-
cockayne
- brd4
-
pausing
-
snrnp
- tbp
- rad3-related
-
cdk-activating
-
bromodomains
- xrcc4
-
pikks
-
promoter-proximal
- rad51
-
paused
-
ir-induced
-
end-binding
- drb
- flavopiridol
-
artemis
-
unrepaired
-
gammah2ax
-
transcription-coupled
-
t-loop
-
atm-dependent
-
dsb-induced
- rpb1
-
atm-deficient
- medicine
Reaction Schemes
showSynonyms
dna-pk, tfiih, p-tefb, dna-dependent protein kinase, positive transcription elongation factor b, kin28, ctd kinase, srb10, ctdk-i, tfiih kinase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Bur1
C-terminal domain kinase
C-terminal repeat domain kinase
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-
-
-
cdk7
CDK8
CDK9
Crk1
CTD kinase
CTD kinase I
Ctdk-1
CTDK-I
CTK-1
Ctk1
Ctk1 kinase
dCDK12
EC 2.7.1.141
-
-
formerly
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Kin28
kinase, ribonucleate nucleotidyltransferase II C-terminal domain (phosphorylating)
-
-
-
-
kinase, ribonucleate nucleotidyltransferase isozyme II IIa subunit (phosphorylating)
-
-
-
-
Lsk1
Mcs6
mitotic catastrophe suppressor 6
P-TEFb
positive transcription elongation factor b
RNA pol II C-terminal domain kinase
RNA Pol II CTD kinase
RNA polymerase II carboxyl terminal domain kinase complex
RNA polymerase II CTD kinase
RNA polymerase II kinase
RNAPII CTD kinase complex
Srb10
TFIIH
additional information
CTD kinase
-
-
-
-
RNA polymerase II CTD kinase
-
-
-
-
additional information
-
the enzyme is organized in the CDKC-1/CYCLINT-1 kinase complex, see also EC 2.7.11.22
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + [DNA-directed RNA polymerase] = ADP + phospho-[DNA-directed RNA polymerase]
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[DNA-directed RNA polymerase] phosphotransferase
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.
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CAS REGISTRY NUMBER
COMMENTARY
122097-00-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
Substrates: the recombinant GST-tagged CTD substrate is hyperphosphorylated by Kin28
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ATP + chicken myosin regulatory light-chain
ADP + chicken myosin regulatory light-chain phosphate
-
Substrates: -
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?
ATP + CTD-containing fusion protein
ADP + phosphorylated CTD-containing fusion protein
-
Substrates: -
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?
ATP + GST-tagged yCTD fusion protein
?
Substrates: hCDK13 purified from nuclear extracts displays CTD kinase activity in vitro with recombinant GST-tagged yeast CTD fusion proteins as substrate, hyperphosphorylation of the CTD by hCDK13 kinase
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ATP + hepta-six peptide
ADP + phosphorylated hepta-six peptide
-
Substrates: -
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?
ATP + holo-RNA polymerase II
?
-
Substrates: C-terminal domain phosphorylation by the serine 5-specific TFIIH complex, its kinase module TFIIK or by the C-terminal domain serine 2-specific kinase CTDK1
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ATP + L-Arg-hepta peptide
ADP + phosphorylated L-Arg-hepta peptide
-
Substrates: -
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?
ATP + numatrin
ADP + phosphonumatrin
-
Substrates: and other nuclear proteins
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?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal domain
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
ATP + RNA polymerase II C-terminal repeat domain
ADP + phosphoylated RNA polymerase II C-terminal repeat domain
ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
ATP + RNA polymerase II carboxy terminal domain
ADP + phosphorylated RNA polymerase II carboxy terminal domain
ATP + Rps2
?
-
Substrates: phosphorylates on Ser 238, phosphorylation of Rps2 is needed for translational accuracy
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?
ATP + synthetic peptide
ADP + phosphorylated synthetic peptide
-
Substrates: -
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?
ATP + [carboxy terminal domain of RNA polymerase II]
ADP + phospho-[carboxy terminal domain of RNA polymerase II]
-
Substrates: the enzyme GSK-3 phosphorylates the carboxy terminal domain of RNA polymerase II in vitro, but preferentially when the substrate is previously phosphorylated, consistently with the requirement of a priming phosphorylation reported for GSK-3 efficacy
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
ATP + [RNA polymerase II carboxyl terminal domain]
ADP + phospho-[RNA polymerase II carboxyl terminal domain]
dATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
dADP + ?
-
Substrates: -
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?
ATP + casein
ADP + phosphocasein
-
Substrates: phosphorylated at about 30% the rate of RNA-polymerase II subunit
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?
ATP + casein
ADP + phosphocasein
-
Substrates: phosphorylated at about 30% the rate of RNA-polymerase II subunit
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?
ATP + CTD-containing fusion proteins
ADP + ?
-
Substrates: e.g. GAL4-CTD (formerly GC147) or HSP 90
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?
ATP + CTD-containing fusion proteins
ADP + ?
-
Substrates: -
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?
ATP + histone H3
?
-
Substrates: Ctk1 is essential for H3K36 methylation, also regulates H3K4 methylation
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?
ATP + histone H3
?
-
Substrates: Ctk1 is essential for H3K36 methylation, also regulates H3K4 methylation
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?
ATP + HIV Tat
ADP + phosphorylated HIV-Tat
-
Substrates: Tat is an efficient substrate for DNA-PK only in the presence of DNA, three putative target sites of DNA-PK phosphorylation
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?
ATP + RNA polymerase II
?
-
Substrates: phosphorylation on C-terminal domain
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?
ATP + RNA polymerase II
?
Substrates: both cdk7 and cdk9 are responsible for phosphorylation at the C-terminal domain
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?
ATP + RNA polymerase II
?
-
Substrates: CDK9 phosphorylates the C-terminal domain on serine 5
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?
ATP + RNA polymerase II
?
-
Substrates: TFIIH and mediator phosphorylate at C-terminal domain at Ser 5, Ser5 phosphorylation by the yeast Cdk7 (Kin28) subunit of TFIIH is required for recruitment of capping enzyme to the promoter region, P-TEFb phosphorylates at Ser 2
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?
ATP + RNA polymerase II
?
-
Substrates: C-terminal domain phosphorylation is required for co-transcriptional splicing
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?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal domain
Substrates: -
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?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal domain
Substrates: the SRI domain of Set2 interacts with the phosphorylated CTD of elongating RNAPII leading to methylation of the chromatin during transcription
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ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: Ctk1 kinase activity regulates H3K4 methylation, the Ctk2 and Ctk3 components of CTDK-1 are necessary for Ctk1 kinase activity, overview
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?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: TFIIH, a 10-subunit complex with many resident enzymatic activities, is essential for transcription by RNA polymerase II involving the TFIIH-associated kinase, Cdk7, which phosphorylates the C-terminal domain, CTD, of Rpb1, the largest subunit of Pol II
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?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: Cdk7 phosphorylates the C-terminal domain, CTD, that consists of multiple YSPTSPS heptapeptide repeats, at Ser5
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?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: phosphorylation at Ser5, phosphorylation patterns, overview
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?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: Ctk1 kinase activity regulates H3K4 methylation, the Ctk2 and Ctk3 components of CTDK-1 are necessary for Ctk1 kinase activity, overview
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?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: phosphorylation at Ser5, phosphorylation patterns, overview
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?
ATP + RNA polymerase II C-terminal repeat domain
ADP + phosphoylated RNA polymerase II C-terminal repeat domain
-
Substrates: hyperphosphorylation, the Mediator complex associates with RNA polymerase II, RNAPII, at least partly via the RNAPII C-terminal repeat domain, CTD, whose phosphorylation is involved in triggering promoter clearance
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ATP + RNA polymerase II C-terminal repeat domain
ADP + phosphoylated RNA polymerase II C-terminal repeat domain
-
Substrates: i.e. RNAPII CTD, hyperphosphorylation, the target specificity of TFIIK and CTDK1 differm, TFIIK phosphorylates Ser5, while CTDK1 phosphorylates Ser2
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ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: Positive transcription elongation factor b is the major metazoan RNA polymerase II carboxyl-terminal domain Ser2 kinase, P-TEFb is critical for the maturation of RNA PolII into productive elongation in vivo, overview
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?
ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: phosphorylation of Ser2
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?
ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
Substrates: i.e. RNAP II CTD, hypophosphorylated form of RNAP IIa is recruited to the preinitiation complex at the gene promoter by the general transcription factors. Initiation proceeds when the cdk7 complex phosphorylates the CTD at the serine 5 residues, resulting in a hyperphosphorylated RNAP II that recruits the RNA-capping enzymes, overview
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ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: the TFIIH mediator complex plays essential roles in transcription initiation and during the transition from initiation to elongation by transmitting signals from transcriptional activators to RNA polymerase II, phosphorylation of the C-terminal domain of RNA polymerase II plays central roles in the integrated events of eucaryotic gene expression, it is not only essential for transcription, but also as a platform for RNA processing and chromatin regulation, detailed overview
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ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: i.e. Pol II CTD, TFIIH and mediator phosphorylate Ser5 of the CTD heptapeptide repeat sequence
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?
ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
Substrates: i.e. RNAP II CTD, phosphorylation at Ser5
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?
ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: the enzyme regulates transcription elongation at many genes and integrates mRNA synthesis with histone modification, pre-mRNA processing, and mRNA export. Recruitment of P-TEFb to target genes requires deubiquitination of H2Bub, phosphorylation of H3S10, and the bromodomain protein, Brd4, overview. P-TEFb accompanies the mature mRNA to the cytoplasm to promote translation elongation. Enzyme regulation system, detailed overview
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?
ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
-
Substrates: phosphorylation at Ser2, Ser5, and Ser7, the extended C-terminal domain, CTD, of the Rbp1 subunit contains 52 heptad repeats with a consensus sequence YSPTSPS
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?
ATP + RNA polymerase II carboxy terminal domain
ADP + phosphorylated RNA polymerase II carboxy terminal domain
-
Substrates: the phosphorylated RNAPII CTD, interacts with BRCA1 for induction of DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD, overview
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?
ATP + RNA polymerase II carboxy terminal domain
ADP + phosphorylated RNA polymerase II carboxy terminal domain
-
Substrates: i.e. RNAPII CTD
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?
ATP + Rps2
ADP + phosphorylated Rps2
-
Substrates: a protein of the small ribosomal subunit, Ctk1 interacts with the transcription and mRNA export, TREX, complex, which couples transcription to mRNA export, and Ctk1 enhances efficient and accurate translation of the mRNA, Ctk1 is a prerequisite for correct decoding in vivo overview
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?
ATP + Rps2
ADP + phosphorylated Rps2
-
Substrates: a protein of the small ribosomal subunit, phosphorylation at Ser238
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?
ATP + synthetic peptides
ADP + ?
-
Substrates: e.g. Lys-(Tyr-Ser-Pro-Thr-Ser-Pro-Ser)4
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?
ATP + synthetic peptides
ADP + ?
-
Substrates: hepta-six or Arg-hepta
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?
ATP + synthetic peptides
ADP + ?
-
Substrates: bovine serum albumin conjugated to heptapeptide
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: -
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies)
-
Substrates: -
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies)
-
Substrates: phosphorylates not Tyr-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies)
-
Substrates: phosphorylates to a lesser extent Thr-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies)
-
Substrates: phosphorylates predominantly Ser-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies)
-
Substrates: the CTD is essential for viability, although mutants with deletions that remove approximately half of the repeats are still viable
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies) Kc
-
Substrates: -
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies) Kc
-
Substrates: phosphorylates not Tyr-residues
Products: -
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies) Kc
-
Substrates: phosphorylates to a lesser extent Thr-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
Drosophila sp. (in: flies) Kc
-
Substrates: phosphorylates predominantly Ser-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: -
Products: -
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: phosphorylates not Tyr-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: kinase CTDK1: 33 mol phosphate per mol IIA-subunit
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: kinase CTDK1 almost exclusively phosphorylates Ser-residues
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: phosphorylates Ser- and Thr-residues equally
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: kinase CTDK2 phosphorylates to a lesser extent Thr-residues
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: kinase CTDK2: 40-50 mol phosphate per mol IIA-subunit, i.e. 1 phosphate per heptapeptide repeat
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: phosphorylates predominantly Ser-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: presumably obligate part of transcription process
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: -
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: no substrates are dTTP and AMP-PNP
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: no substrates are the RNA polymerases II of Drosophila melanogaster and yeast
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: no substrates are CTP and UTP
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: presumably obligate part of transcription process
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: the CTD is essential for viability, although mutants with deletions that remove approximately half of the repeats are still viable
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: -
Products: -
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: no substrate is phosvitin
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: phosphorylates not Tyr-residues
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: phosphorylates to a lesser extent Thr-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: phosphorylates predominantly Ser-residues
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?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: presumably obligate part of transcription process
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: CTD kinase 1 plays an important role in transcription elongation in vivo, the deletion of one ore more CTK genes is lethal but in combination with the deletion of PPR2 or ELP
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: deletion of the kinase subunit Ctk1 results in phosphorylation of serine in position 5 of the CTD repeat during logarithmic growth and eliminates the transient increase in CTD serine 2 phosphorylation during the diauxic shift
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: the CTD is essential for viability, although mutants with deletions that remove approximately half of the repeats are still viable
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: CTD kinase I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: -
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: phosphorylates to a lesser extent Thr-residues
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: no substrates are bovine serum albumin and calf thymus histone
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: no substrate is GTP
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: phosphorylates predominantly Ser-residues
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: substrates are RNA-polymerase II subunits of wheat germ, soy bean, pea and human
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: distinct from other protein phosphokinases, transfers about 20 phosphates to the heptapeptide repeats Pro-Thr-Ser-Pro-Ser-Tyr-Ser in C-terminal domain of MW 220000 subunit of RNA-polymerase II
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: no substrates are CTP and UTP
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ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
-
Substrates: presumably obligate part of transcription process
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ATP + [DNA-directed RNA polymerase II]
ADP + phospho-[DNA-directed RNA polymerase II]
-
Substrates: Cdk12 acts on the Ser2 residue in Pol II CTD heptad repeats
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ATP + [DNA-directed RNA polymerase II]
ADP + phospho-[DNA-directed RNA polymerase II]
Substrates: only Rpb1, the largest subunit of RNAPII evolved a unique, highly repetitive carboxy-terminal domain, termed CTD. Dynamic phosphorylation patterns of serine residues in the CTD during gene transcription. Phosphorylation of Ser2, Ser5, Thr4, and Tyr1 in the CTD. CTD is composed of multiple tandem heptapeptides with the evolutionary conserved consensus motif Tyr1-Ser-Pro3-Thr4-Ser5-Pro6-Ser7
Products: -
Products: -
?
ATP + [DNA-directed RNA polymerase II]
ADP + phospho-[DNA-directed RNA polymerase II]
Substrates: only Rpb1, the largest subunit of RNAPII evolved a unique, highly repetitive carboxy-terminal domain, termed CTD. Dynamic phosphorylation patterns of serine residues in the CTD during gene transcription. Phosphorylation of Ser2, Ser5, Thr4, and Tyr1 in the CTD. CTD is composed of multiple tandem heptapeptides with the evolutionary conserved consensus motif Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7
Products: -
Products: -
?
ATP + [DNA-directed RNA polymerase II]
ADP + phospho-[DNA-directed RNA polymerase II]
Substrates: the cyclin-dependent kinase subunit Cdk7