EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.11.23 | ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa] |
- |
Aspergillus sp. |
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa] |
- |
? |
2.7.11.23 | ATP + RNA polymerase II |
phosphorylation on C-terminal domain |
Drosophila melanogaster |
? |
- |
? |
2.7.11.23 | ATP + RNA polymerase II C-terminal subunit |
Positive transcription elongation factor b is the major metazoan RNA polymerase II carboxyl-terminal domain Ser2 kinase, P-TEFb is critical for the maturation of RNA PolII into productive elongation in vivo, overview |
Drosophila melanogaster |
ADP + phosphoylated RNA polymerase II C-terminal subunit |
- |
? |
2.7.11.23 | ATP + RNA polymerase II C-terminal subunit |
phosphorylation of Ser2 |
Drosophila melanogaster |
ADP + phosphoylated RNA polymerase II C-terminal subunit |
- |
? |
2.7.11.23 | ATP + [DNA-directed RNA polymerase II] |
Cdk12 acts on the Ser2 residue in Pol II CTD heptad repeats |
Drosophila melanogaster |
ADP + phospho-[DNA-directed RNA polymerase II] |
- |
? |
2.7.11.23 | ATP + [DNA-directed RNA polymerase II] |
only Rpb1, the largest subunit of RNAPII evolved a unique, highly repetitive carboxy-terminal domain, termed CTD. Dynamic phosphorylation patterns of serine residues in the CTD during gene transcription. Phosphorylation of Ser2, Ser5, Thr4, and Tyr1 in the CTD. CTD is composed of multiple tandem heptapeptides with the evolutionary conserved consensus motif Tyr1-Ser-Pro3-Thr4-Ser5-Pro6-Ser7 |
Drosophila melanogaster |
ADP + phospho-[DNA-directed RNA polymerase II] |
- |
? |
2.7.11.23 | ATP + [DNA-directed RNA polymerase II] |
only Rpb1, the largest subunit of RNAPII evolved a unique, highly repetitive carboxy-terminal domain, termed CTD. Dynamic phosphorylation patterns of serine residues in the CTD during gene transcription. Phosphorylation of Ser2, Ser5, Thr4, and Tyr1 in the CTD. CTD is composed of multiple tandem heptapeptides with the evolutionary conserved consensus motif Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7 |
Drosophila melanogaster |
ADP + phospho-[DNA-directed RNA polymerase II] |
- |
? |
2.7.11.23 | ATP + [DNA-directed RNA polymerase II] |
the cyclin-dependent kinase subunit Cdk7 of TFIIH phosphorylates Ser5 and Ser7 |
Drosophila melanogaster |
ADP + phospho-[DNA-directed RNA polymerase II] |
- |
? |
2.7.11.23 | ATP + [DNA-directed RNA polymerase II] |
the cyclin-dependent kinase subunit Cdk8 of the Mediator phosphorylates CTD Ser5 |
Drosophila melanogaster |
ADP + phospho-[DNA-directed RNA polymerase II] |
- |
? |
2.7.11.23 | ATP + [DNA-directed RNA polymerase] |
CTD phosphorylation and transcription cycle overview |
Drosophila melanogaster |
ADP + phospho-[DNA-directed RNA polymerase] |
- |
? |