EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   2.4.2.64 | guanine34 in tRNA + 7-(aminomethyl)-7-deazaguanine |
the affinity of the rat liver tRNA-guanine transglycosylase for queuine is much greater than that for 7-(aminomethyl)-7-deazaguanine and guanine |
Rattus norvegicus |
7-(aminomethyl)-7-deazaguanine34 in tRNA + guanine |
- |
? |
| 2.4.2.64 | guanine34 in tRNA + 7-aminomethyl-7-carbaguanine |
very low activity with wild-type enzyme. The mutant enzyme V161C exhibits a significant improvement in preQ1 (7-aminomethyl-7-deazaguanine) recognition |
Homo sapiens |
7-aminomethyl-7-carbaguanine34 in tRNA + guanine |
- |
? |
| 2.4.2.64 | more |
- |
Escherichia coli |
? |
- |
? |
| 2.4.2.64 | more |
key enzyme involved in the incorporation of the modified base queuine into tRNA |
Escherichia coli |
? |
- |
? |
| 2.4.2.64 | more |
higher expression of the subunit TGT60KD in cancer cells than in normal cells. The expression levels of the TGT60KD subunit regulate enzyme activity and the level of queuosine. TGT60KD plays significant roles in carcinogenesis |
Homo sapiens |
? |
- |
- |
| 2.4.2.64 | more |
the enzyme is required for virulence |
Shigella flexneri |
? |
- |
? |
| 2.4.2.64 | more |
the 60000 Da subunit of the enzyme plays a role in colon carcinogenesis |
Homo sapiens |
? |
- |
- |
| 2.4.2.64 | dihydroqueuine + tRNAguanine |
- |
Xenopus laevis |
guanine + tRNAdihydroqueuine |
- |
? |
| 2.4.2.64 | guanine34 in tRNA + queuine |
- |
Drosophila melanogaster |
queuine34 in tRNA + guanine |
- |
? |
| 2.4.2.64 | guanine34 in tRNA + queuine |
- |
Escherichia coli |
queuine34 in tRNA + guanine |
- |
r |
