Information on Organism Rattus norvegicus

P36970

in the blastomeres, Gpx4 granules are formed, and in the blastocysts, even clusters are present mainly around the cell nuclei

in the blastomeres, Gpx4 granules are formed, and in the blastocysts, even clusters are present mainly around the cell nuclei

bone marrow cell line

adult bone marrow-derived insulin-producing cells, presence of transketolase protein under high-glucose conditions

695145

bone marrow stromal cell

bone marrow stromal stem cell

brain cortex cell line

brain microvascular endothelial cell

brain microvessel endothelial cell

681931

plasma membrane vesicles from brain microvessel endothelial cells

713241

brain myelin

labeled product also found in vitro in brain tissue slices

breast cancer cell line

carcinoma

1391, 679130, 776212

658797, 668500, 672968

bronchoalveolar lavage

bronchoalveolar lavage fluid

650339

647183, 658797, 668500, 695488

Q4FZY2

cardiomyocyte cell line

cardiovascular system

cavum septum pellucidum

presence of enzyme immunoreactive material at birth, progressive reduction with age with complete loss at postnatal day 18

682134

CBRH-7919 cell

central amygdaloid nucleus

a rat hepatoma cell line established from N-nitrosodiethyla-mine-induced Wistar rat hepatoma

Q7TNJ7

666110

central nervous system

11 entries

cerebellar cortex

9 entries

cerebellar granule cell

cerebellar granule neuron

P20070

693768, 700193, 710518

712873

cerebellar Purkinje cell

cerebral cortical neuron

P13255, P18266

688660, 691554, 692085, 693721, 693777, 693779, 694359, 694395, 697348, 699690, 701003, 702959, 704524, 704782, 708434, 713549, 717193, 718019, 734538, 774712

cerebral granule cell

P37136

compared to the canonical AChE-S splice variant, the readthrough splice variant AChE-R is expressed at much lower levels but presents distinct regulation patterns in PC-12 cells and rat primary cerebral granule cells following exposure to pesticide chlorpyrifos

769041

cerebral hemisphere

cerebral white matter

enriched in GRK2 and GRK5

chondrosarcoma cell line

choroid

FAEES activity is increased 4fold in the choroid of alcohol-treated rats compared with controls

209381, 209382, 683383, 758876

cingulate cortex

circular smooth muscle

colonic cancer cell line

colorectal carcinoma cell

gamma-glutamyltransferase is upregulated after oxidative stress through the Ras signal transduction pathway in rat colon carcinoma cells

686893

colonic carcinoma cell

commercial preparation

coronary artery endothelial cell

Corpus cavernosum smooth muscle

7th cranial nerve

1222, 672982

pulmonary artery smooth muscle cell line

secretion of active enzyme is stimulated by thyrotropin, insulin, and/or somatostatin

667984, 668394, 699331, 699442, 754400, 770583

dental papilla

P29476

dental papilla cells (DPCs) are mesenchymal cells that are surrounded by the enamel organ during tooth development

incisor

208880, 208881, 686294

diaphragm

P15791

209031, 286863, 394810, 394817, 487432, 491258, 654168, 669619, 706844, 774213

diencephalon

O35078

658240, 679665, 688608

mRNA of FTA and FTC

duodenal luminal fluid

high activity at pH 4.5

683802

duodenal mucosa

E-18 rat primary hippocampal neuron

O35547, O88813, P18163, P33124, Q63151

114243, 675267, 697058

duodenum

6 entries

ear

egg

embryonic fibroblast cell line

embryonic hippocampal cell line

embryonic neural stem cell

712829

NRP and GRP-neuronal and glial restricted precursors are isolated from embryonic day 13.5 rats and transplantated into rats.

694593

endocardium

in healthy hearts, DDAHI is absent, and DDAHII is localized to endothelium and endocardium with a similar distribution to that of eNOS

710771

endocrine pancreas

endocrine islets of Langerhans

endometrial stromal cell

enzyme is found in luminal and glandular epithelial cells and in stroma during late pregnancy

enteric nervous system

enterochromaffin-like cell

isozyme PGF synthase II

brain

epididymal clear cell

epitrochlearis muscle

ER-1 cell

esophageal adenocarcinoma cell

ER-1-24h, ER-1-1M cell produced

extensor digitorum longus

extraocular muscle

isoenzyme CA3 is depressed, message levels of isoenzyme CA2 and CA4 are higher in extraocular muscle than in extensor digitorum longus, expression of isoenzyme CA5 is equivalent in extraocular muscle and extensor digitorum longus

eye

668421, 750010, 760043

fascia

follicular thyroid carcinoma cell line

699329

fast twitch muscle fiber

glycolytic fiber

hepatoma cell line

mainly

primary fiber cells

FTC133 and FTC236

Friend erythroleukemia cell line

664474, 682128, 683322, 683791, 689087, 700461, 705922, 730236

672441, 672452, 673597, 704541, 704621

from spinal cord

relationship between expression level of the enzyme and mucosal proliferation, overview

gastric smooth muscle

gastrointestinal cancer cell

glomerular endothelial cell

733064

gastrointestinal tract

external

glomerular epithelial cell

important role for Rho-GTPases in the morphology and function of glomerular epithelial cells. Activation of RhoA appears to be protective against complement-mediated injury

age-related changes in immunoreactivity for dopamine beta-hydroxylase in carotid body glomus cells in spontaneously hypertensive rats

northern blot

myosin ATPase isoenzymes show different temperature sensivities

246988

granular insular cortex

forebrain and cerebral cortex

439437, 638234, 671253

inguinal white adipose tissue

gut

Reuber hepatoma cell line

a derivative of the H4-IIE-C3 rat hepatoma cell line

hair follicle epithelium

a microglial cell line

5119, 210708, 486820, 489953, 718751, 734602

HEK-293 PEAKrapid cell

hematopoietic stem cell

R-type isozyme

in embryos at 12.5 days of gestation guanidinoacetate N-methyltransferase is detectable in the hepatic primordium only, with all other tissues being negative. Non-radioactive in situ hybridization (58°C for 40 h in 5 x SSC, 50% formamide and 40 microg/ml salmon sperm DNA) with digoxigenin-labeled antisense and sense riboprobes (400 ng/ml) for rat guanidinoacetate N-methyltransferase. guanidinoacetate N-methyltransferase proteins are detected with rabbit polyclonal antibodies

672798

hepatic stellate cell

hepatocellular carcinoma cell

hepatoma ascites cell line

hepatocyte

48 entries

hepatoma ascites cell

6 entries

somatostatin-sensitive enzyme form

649569

hindlimb

hippocampal cell line

hippocampal pyramidal layer

P17105

699694, 700089, 735134

glutathione-requiring enzyme

O35776, Q8CH92, Q8CH93

tumorigenic cell line, 3-5fold higher hyaluronan accumulation than in the parental cell line 3Y1

treatment with ascorbate in a hypoxic condition for 24 h results in the maximal increase of hydroxyproline by 1.8-fold. The presence of cobalt chloride can substitute for hypoxic condition

intestinal cell line

forebrain and cerebral cortex

694399

inguinal canal

O35547, O88813, P18163, P33124, Q63151

inguinal adipose tissue

677468, 735423, 747484, 771400

693436, 721548, 738594, 748220, 764207

insulinoma cell

intestinal epithelial cell

A0A0G2K502, A6H9Z9, D3ZU86, D4A4P4, F1M5N4

81296, 661681, 693436, 695884, 704688, 738594, 741010, 752703, 778544

lateral entorhinal cortex

Q64232

740725

intestinal epithelium

P07314, P13264, P19468

keratinocyte cell line

acini

lateral geniculate nucleus

forebrain and cerebral cortex

694399

laterodorsal tegmental nucleus

thalamus and hypothalamus

laterodorsal thalamic nucleus

686293

thalamus and hypothalamus

the active caspase-3 expression is higher in the anterior pole of the lens

731094

leptomeninx

Lewis lung carcinoma cell

cultivated rat leptomeningeal cells

diethylnitrosamine-induced liver tumor

rat liver cell line

liver parenchymal cell

liver sinusoidal endothelial cell

741248

lung cancer cell line

shows HSL staining in cytoplasm during proestrus and estrus, in the nucleus during metestrus, and in cytoplasm and the nucleus during diestrus

tumorigenic cell line derived from OC22 by reiterated treatment with N-methyl-N-nitro-N-nitrosoguanidine

NOX2 and NOX4 are the main isoforms present in macula densa cells

mammary carcinoma cell

medial geniculate nucleus

mammary epithelial cell

no statistically significant difference in the amount of enzyme between tumors with and without activated H1-ras oncogene

209936, 438244, 681551

a prostate cancer cell line

673432

mature ovarian follicle

1710, 4771, 36122, 654375, 662463, 680820, 690298, 693822, 704909, 714316, 717762, 748626

medial mammillary nucleus

683791

medial pterygoid muscle

12 to 14% of cell profiles express pyroglutamyl peptidase II mRNA in the medial septum-diagonal band of Broca, in this region the specific activity of the enzyme is relatively high. Injection of the pyroglutamyl peptidase II inhibitor p-Glu-Asn-Pro-7-amido-4-methylcoumarin into the medial septum enhances the effect of thyrotropin-releasing hormone. The injection of a phosphinic thyrotropin-releasing hormone analog, a higher affinity inhibitor of pyroglutamyl peptidase II, diminishes the duration of ethanol-induced loss of righting reflex by itself

DGKbeta is expressed in medium spiny neurons constituting the striatonigral and striatopallidal pathways, whereas striatal interneurons are below the detection threshold

703560

medulla oblongata

6 entries

medullary carcinoma cell

medullary collecting duct

658976

medullary thyroid carcinoma cell

749543

mouse embryonic fibroblast

primary embryonic metanephric mesenchymal cells

773783

mesenchymal stem cell

mesenchymal stromal cell

from bone marrow

mesenteric lymph node

209015, 699331, 733064

mesentery

microvascular endothelial cell

658885, 682620, 707783

80887, 393046, 393057, 488947, 644640, 644648, 653657, 665964

macula densa cell line, significantly lower enzyme levels than in a proximal tubule cell line. Treatment with an inhibitor of cyclooxygenase-2 increases enzyme level

655495, 668394, 671253, 707951, 777419

mononuclear cell

Morris hepatoma 3924A cell

Morris hepatoma 7316A cell

Morris hepatoma 7777 cell

758771

Morris hepatoma 7800C1 cell

36202, 36211, 641735

Morris hepatoma tumors 9618A2, 7777, 5123TC, 7800, 5123B, 7787

primary, different layers

mucinous ovarian adenocarcinoma cell

primary

stomach

soleus muscle

EDL muscle

amplified by PCR from

682679

myelomonocytic leukemia cell

GRK2

neuropil, tyrosine hydroxylase-immunoreactive nerve terminals are distributed throughout the ganglia and contained exclusively pleomorphic clear synaptic vesicles

phosphodiesterase 5

neuroblastoma cell

T-lymphoma cell, exclusive synthesis of isoform SPD-N

667510

Nb2-Sp cell

neuron-oligodendrocyte co-culture

lymphoma cell, exclusive synthesis of isoform SPD-N

enzyme activity is well-maintained in the dissociated neostriatal neurons

preganglionic

Novikoff ascites hepatoma cell

Q9R1T5

neurons from wild-type embryos are co-cultured with oligodendrocytes prepared from either wild-type or tremor rats

fibroblast cells

Novikoff ascites tumor cell

645139

Novikoff hepatoma cell

NR-8383 cell

nucleus tractus solitarii

702430, 715663, 732724

a pivotal region in reflex regulation of arterial pressure in the brain stem. Quantitative determination of expression levels of specific class I PI3K subunits, p85alpha, p85beta, p110alpha, p110beta, p110delta, and p110gamma, in the nucleus tractus solitarii of spontaneously hypertensive rats, overview

708686

NW-16 cell

transformed fibroblast cell line

667541

OC/CDE22 cell

olfactory ensheathing cell

a non-tumorigenic cell line of oval cells established from livers of rats undergoing carcinogenesis by the choline deficient/ethionine-supplemented diet for 12 weeks

on the dental root side, expression pattern of cathepsin K, high expression level in the age of 4-5 weeks, when physiological root resorption occurs actively, co-expression with matrix metalloproteinase-9

490284, 691934, 710451, 760044, 772436

olfactory receptor neuron

the olfactory receptor neurones (replaceable) appear to be strongly immunoreactive as do the principal neurones (mitral and mitral/tufted cells), while in the olfactory bulb the replaceable periglomerular and granule cells appear to be non-reactive, distribution in cellular compartments, overview

ovarian granulosa cell

ovarian theca-interstitial cell

NTPDase1

698165

rhabdomyosarcoma cell

697057

pancreas

46 entries

pancreatic acinar cell

pancreatic beta cell line

pancreatic beta cell

10 entries

pancreatic islet cancer cell

A6H9Z9

778544

pancreatic islet cell

pancreatic juice

80819, 210134, 683802

parahippocampal region

paraventricular nucleus

paraventricular nucleus of hypothalamus

P29476

705267, 708686, 763849

aldosterone-insensitive, NADP+ specificity

paw

clonal derivative of PC12 cell line

669295

PC6-3 cell

periaqueductal gray matter

neuronal cell line, derived from PC12 cell line

PNN

from heart and abdominal aorta

701687

peripheral blood mononuclear cell

NMT activity is observed to be 3fold higher in peripheral blood mononuclear cells from rats with colonic cancer than in controls, and shows also differential localization

719244

peripheral nerve

peripheral nervous system

perirhinal cortex

significantly increased agmatine levels in the prefrontal, entorhinal, and perirhinal cortices in a T-maze training group relative to the control group

692560

peritoneal macrophage

peritoneum

O35776, Q8CH92, Q8CH93

29374, 439437, 440208, 440213, 656450, 656451, 659334

peritubular cell

pituitary gland cell line

perivascular astrocyte

pheochromocytoma cell

the selective distribution of isozyme DAGKepsilon in photoreceptor cells is a light-dependent mechanism that promotes increased 1-stearoyl, 2-arachidonoylglycerol removal and synthesis of 1-stearoyl, 2-arachidonoyl phosphatidic acid in the sensorial portion of this cell

shows high levels of expression for beta1 mRNA and moderate for alpha1 and alpha2 mRNAs

7 entries

pituitary gland tumor cell

GH3 tumour

originated from kidney

16278, 171169, 486640, 644501, 650365, 652153

immortalized rat granulosa cell line

656638

polymorphonuclear leucocyte

polymorphonuclear leukocyte

735626

polymorphonuclear neutrophil

660111

AC2

posterior thalamic nucleus

thalamus and hypothalamus

26853, 26858, 26866, 26868, 36642, 171565, 396193, 718751

primary cell

710106, 710108, 764825

primary cell line

prostate cancer cell line

mixed neuron-glial cultures prepared from the brains of embryonic days 16-17 rats

705941

primary cerebral neuron

cerebellar

prostate gland anterior lobe

682214

prostate carcinoma cell

prostate gland cancer cell

671210

prostate gland ventral lobe

prostate tumor

697471

mRNA of FTA, FTB and FTC

489369

proximal tubule

proximal tubule epithelium

394186, 485968, 485971, 640182, 670957, 673003, 675725, 712134, 747727

proximale tubular epithelium

741796

4667, 4669, 4673

pulmonary artery endothelial cell

pulmonary artery smooth muscle cell

684357, 732912

pulp

renal cell carcinoma cell

heat stress enhances ALP activity in pulp cells

pup

Cornu Ammonis 1 pyramidal cells

renal cortical collecting duct cell line

Q6AYS7

697141

renal collecting tubule

P36365, Q8K4B7, Q9EQ76

in distal tubular cells, adiponectin through luminal ADIPOR1 activates AMPK, leading to the inhibition of glycogen synthase. During hyperglycemia, this regulation is altered, which may explain, at least in part, the accumulation of large glycogen deposits

684374

renal epithelium

renal glomerular podocyte

P36365, Q8K4B7, Q9EQ76

662585, 705314, 747727

renal proximal tubule

P13255, P15684, Q76IC5, Q9QX71

657686, 667884, 695499, 704524, 718063, 720830, 752601

renal tubule

7 entries

renal tubule epithelium

respiratory bronchiole

retinal ganglion cell

retinal pigment epithelial cell

retinal pigment epithelium

704107, 704797

retinal pigment epithelium cell

686598, 717275

699690, 700089, 774376

RGC-5 cell

ischemic retinal ganglion cells

gastric mucosal cell

liver cell line

a retinal Mueller cell line, enzyme expression analysis, uptake of D-serine in Mueller cells is specific for neutral amino acids and excludes anionic and cationic amino acids, specificity and activity of transporters, overview

raphe cell line

rat osteosarcoma cell line

662910

rostral migratory stream

rostral ventrolateral medulla

in neonatal animals, small, moderately stained NADPH-d-positive cells are identified in the vertical arm and in the elbowv of the rostral migratory stream. In adult and aging rats a few labeled cells could be also detected in the RMS horizontal arm. The number of NADPH-d-positive cells increases with advancing age

673008

Rous sarcoma cell

virus-transformed and normal

scleral lamina cribrosa

seminiferous epithelium

layers III and V

752416, 761130, 774724, 776089

skeletal muscle fiber

skeletal muscle satellite stem cell

698991

in culture

small intestine epithelium

94272, 438259, 698170

small intestine mucosa

primary, different layers

O35776, Q8CH92, Q8CH93

metastatic cell line, 3-5fold higher hyaluronan accumulation than in the parental cell line 3Y1

higher levels of phenylethanolamine N-methyltransferase in stellate ganglia of mice compared with rats. Phenylethanolamine N-methyltransferase mRNA is present in stellate ganglia. Immobilization stress increases the gene expression of phenylethanolamine N-methyltransferase in stellate ganglia of rats, the highest levels of phenylethanolamine N-methyltransferase mRNA are immediatetly after and 3 h after the end of a stressful stimulus, while recovery to control levels occurs 6 h after the termination of immobilization. Immobilization repeated seven times further increases mRNA levels of phenylethanolamine N-methyltransferase in stellate ganglia of rats. There is no change in phenylethanol N-methyltransferase protein levels in stellate ganglia after a single immobilization, but protein levels are increased after repeated immobilization stress exposure.

the paraventricular nucleus of the hypothalamus and the central amygdala

699667

striatal neuron

693746, 705933, 732751

striated muscle

submandibular salivary gland

Q9ET32

A-type enzyme expression

marrow stromal cell-brain microvascular endothelial cell contact coculture and indirect co-culture of marrow stromal cell and brain microvascular endothelial cell

shows high expression of beta1, moderate of alpha2, and low of alpha1

superior cervical ganglion

L-COMT is the predominant enzyme form

superior mesenteric artery

human TAP-deficient lymphoblastoid cell, expressing rat wild-type TAP or single rat TAP1 or TAP2 chains

highest levels of expression in nucleus accumbens, taenia tecta, cerebellar cortex, cerebral cortical layer I, hippocampus, hypothalamus, mesencephalic raphe nuclei, central and lateral amygdala, and the circumventricular organs

649426, 673460, 693876, 742246

672957, 673513, 701630

Tpl-2 isolated from Moloney leukemia virus-induced thymoma cells

695615, 702475, 711688, 728034, 733459, 745617

thyroid epithelial cell

a variety of mammalian cell lines in tissue culture

at the later secretory stage mostly in the outer part of the forming enamel, weakly in inner forming enamel associated with the holes located near the DEJ

urinary bladder cancer cell

urinary bladder endothelial cell

P39052

invasive bladder cancer cell

755945

urinary bladder smooth muscle

P29476, Q06518

698343

uterine leiomyoma cell

Q91V26

673354

uterine smooth muscle

order of hydrogen sulfide production rates for different tissues are: liver (777 nM/min/g), followed by uterus (168 nM/min/g), fetal membranes (22.3 nM/min/g), placenta (11.1 nM/min/g), compared to human placenta (200 nM/min/g)

695079

uterine wall