EC Number   |
Substrates |
Organism |
Products  |
Reversibility |
|---|
   1.14.18.5 | D-erythro-eicosasphinganine + NADH + H+ + O2 |
- |
Zea mays |
4-hydroxyeicosasphinganine + NAD+ + H2O |
- |
? |
| 1.14.18.5 | D-erythro-sphinganine + NADH + H+ + O2 |
- |
Zea mays |
4-hydroxysphinganine + NAD+ + H2O |
free 4-hydroxysphinganine is produced in excised corn shoots by the direct hydroxylation of sphinganine and not from the breakdown of complex sphingolipids |
? |
| 1.14.18.5 | D-erythro-sphinganine + NADPH + H+ + O2 |
- |
Zea mays |
4-hydroxysphinganine + NADP+ + H2O |
- |
? |
| 1.14.18.5 | sphinganine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+ |
- |
Mus musculus |
4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O |
plus (E)-sphing-4-enine ceramide, the (E)-sphing-4-enine/4-hydroxysphinganine ratio is 2.5:1 |
? |
| 1.14.18.5 | dihydroceramide + reduced acceptor + H+ + O2 |
- |
Saccharomyces cerevisiae |
? |
- |
? |
| 1.14.18.5 | dihydroceramide + reduced acceptor + H+ + O2 |
- |
Saccharomyces cerevisiae W303C |
? |
- |
? |
| 1.14.18.5 | more |
DL-threo-sphinganine is not an effective substrate. Individual ceramide species having 2-, 6-,8-, or 24-carbon fatty acyl chains amide-linked to sphinganine are hydroxylated with similar efficiency as free sphinganine |
Zea mays |
? |
- |
? |
| 1.14.18.5 | more |
enzyme is a bifunctional sphingolipid DELTA4-desaturase/C4-hydroxylase, with the desaturase activity being one order of magnitude higher than the hydroxylase activity |
Leishmania major |
? |
- |
? |
| 1.14.18.5 | N-octanoyl-D-erythro-dihydrosphingosine + reduced acceptor + H+ + O2 |
- |
Homo sapiens |
? |
- |
? |
| 1.14.18.5 | N-acetylsphinganine + NADPH + H+ + O2 |
- |
Zea mays |
N-acetyl-4-hydroxysphinganine + NADP+ + H2O |
- |
? |
