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Information on EC 1.14.18.5 - sphingolipid C4-monooxygenase

for references in articles please use BRENDA:EC1.14.18.5
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IUBMB Comments
The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase .
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Word Map
  • 1.14.18.5
  • ubiquitin-conjugating
  • sphingolipids
  • mitosis
  • checkpoint
  • spindle
  • sphingoid
  • anaplastic
  • anaphase-promoting
  • p53-dependent
  • anaphase
  • ube2d2
  • ubiquitin-dependent
The enzyme appears in viruses and cellular organisms
Synonyms
sur2p, sphingolipid c4-hydroxylase, syr2p, sphinganine c4-hydroxylase, sphingolipid hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a dihydroceramide + 2 ferrocytochrome b5 + O2 + 2 H+ = a (4R)-4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O
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