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EC Number
Substrates
Commentary Substrates
Organism
Products
Commentary (Products)
Reversibility
2.7.4.14
dUTP + CMP
-
Rattus norvegicus
dUDP + CDP
-
?
2.7.4.14
GTP + CMP
-
Homo sapiens
GDP + CDP
-
?
2.7.4.14
GTP + CMP
-
Rattus norvegicus
GDP + CDP
-
?
2.7.4.14
GTP + dCMP
-
Homo sapiens
GDP + dCDP
-
?
2.7.4.14
GTP + UMP
-
Homo sapiens
GDP + UDP
-
?
2.7.4.14
ITP + CMP
-
Rattus norvegicus
IDP + CDP
-
?
2.7.4.14
ITP + UMP
-
Rattus norvegicus
IDP + UDP
-
?
2.7.4.14
more
formation of a ternary complex, addition of substrates is random
Homo sapiens
?
-
?
2.7.4.14
more
the UMP-CMP kinase has a relaxed enantiospecificity for the nucleoside monophosphate acceptor site, but it is restricted to D-nucleotides at the donor site
Homo sapiens
?
-
?
2.7.4.14
more
the enzyme is involved in the phosphorylation of nucleic acid precursors, and is critical in the ribo- and deoxyribonucleoside salvage pathway, as well as the anabolic phosphorylation of nucleoside analogues used in viral and anticancer therapies, e.g. cidofovir, which is activated by the enzyme, overview
Homo sapiens
?
-
?
Results
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141
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