EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.7.4.14 | more |
UMP-CMPK2 may have other functions in addition to the supply of substrates for mtDNA synthesis, it is highly expressed in leukemia cells, in bone marrow, and is tightly correlated with macrophage activation and inflammatory response |
Homo sapiens |
? |
- |
? |
2.7.4.14 | more |
substrate/product binding site determination and kinetics using MABA-CDP in a competition assay, overview |
Homo sapiens |
? |
- |
? |
2.7.4.14 | more |
the enzyme shows enantioselectivity, acceptor-binding site structure of human UMP-CMP kinase in the closed form or in ligand-bound forms, overview |
Homo sapiens |
? |
- |
? |
2.7.4.14 | more |
hyperensitivity and resistance against anti-cancer drugs in the different cervical tumour cell lines, effects of changes on UMP/CMPK1 expression on CTP and UTP synthesis , overview |
Homo sapiens |
? |
- |
? |
2.7.4.14 | more |
CMP and UMP are the preferred substrates for purified CMPK, and it has lower affinity to dCMP and dUMP |
Homo sapiens |
? |
- |
? |
2.7.4.14 | more |
mutants P64T/R134M and R134M show no activity with all substrates |
Homo sapiens |
? |
- |
? |
2.7.4.14 | TTP + CMP |
- |
Homo sapiens |
TDP + CDP |
- |
? |
2.7.4.14 | TTP + dCMP |
- |
Homo sapiens |
TDP + dCMP |
- |
? |
2.7.4.14 | TTP + UMP |
- |
Homo sapiens |
TDP + UDP |
- |
? |
2.7.4.14 | UTP + CMP |
- |
Rattus norvegicus |
UDP + CDP |
- |
? |