EC Number   |
General Information |
Reference |
|---|
   3.4.24.B10 | malfunction |
about 30% of ADAM12 deficient mice die during the early neonatal period and 30% of viable homozygotes display a reduction in their interscapular brown adipose tissue. ADAM12 null mice are more resistant to obesity induced by high-fat diet and exhibit improved insulin sensitivity compared to wild type mice |
734873 |
| 3.4.24.B10 | malfunction |
down-regulation of ADAM12L in hepatic stellate cells leads to cytoskeletal disorganization and loss of adhesion |
734657 |
| 3.4.24.B10 | malfunction |
enzyme downregulation in breast cancer cell lines results in reduction of pro-angiogenic factors and endothelial cell recruitment |
754704 |
| 3.4.24.B10 | malfunction |
enzyme inhibition is sufficient to rescue the in vivo neural vasculature under hypoxia from the loss of barrier function |
755405 |
| 3.4.24.B10 | malfunction |
enzyme knockdown greatly enhances interleukin-17-secreting cell differentiation, more potently then inhibiting transforming growth factor beta signals |
735109 |
| 3.4.24.B10 | malfunction |
enzyme knockdown reduces cell migration and invasion, decreases anoikis resistance, and compromises mammosphere formation. Enzyme knockdown lowers the basal activation level of epidermal growth factor receptor pathway |
754703 |
| 3.4.24.B10 | malfunction |
enzyme loss impedes spontaneous fusion of primary cytotrophoblasts |
733623 |
| 3.4.24.B10 | metabolism |
the transforming growth factor-beta1 signaling pathway is correlated with ephrin-A1 cleavage by isoform ADAM12L |
734812 |
| 3.4.24.B10 | metabolism |
up-regulation of ADAM12L induces the Akt Ser-473 phosphorylation-dependent survival pathway via stimulation of beta1 integrins and activation of phosphoinositide 3-kinase, and promotes kinase activity from integrin-linked kinase immunoprecipitates |
734657 |
| 3.4.24.B10 | physiological function |
ADAM12 plays a role in the development of several organs, including the formation of feather buds |
719334 |
