Literature summary for 3.4.24.B10 extracted from

Duhachek-Muggy, S.; Qi, Y.; Wise, R.; Alyahya, L.; Li, H.; Hodge, J.; Zolkiewska, A.
Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer (2017), Mol. Cancer, 16, 32 .

Search for more literature for 3.4.24.B10

Application

Application	Comment	Organism
medicine	the enzyme is a predictor of chemoresistance in estrogen receptor-negative tumors	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
batimastat	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O43184	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
BT-549 cell	-	Homo sapiens	-
Hs-578T cell	-	Homo sapiens	-
SUM-1315MO2 cell	-	Homo sapiens	-
SUM-149PT cell	-	Homo sapiens	-
SUM-159PT cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
a disintegrin and metalloprotease 12	-	Homo sapiens
ADAM12	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is upregulated in human breast cancers	up

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown reduces cell migration and invasion, decreases anoikis resistance, and compromises mammosphere formation. Enzyme knockdown lowers the basal activation level of epidermal growth factor receptor pathway	Homo sapiens
physiological function	breast cancer cell populations with high enzyme levels have elevated expression of cancer stem cell markers and an increased ability to form mammospheres. The enzyme actively supports the cancer stem cell phenotype in claudin-low breast cancer cells via modulation of the epidermal growth factor receptor pathway	Homo sapiens

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Release 2023.1 (January 2023)