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Literature summary for 3.4.24.B10 extracted from

  • Zhou, A.X.; El Hed, A.; Mercer, F.; Kozhaya, L.; Unutmaz, D.
    The metalloprotease ADAM12 regulates the effector function of human Th17 cells (2013), PLoS ONE, 8, e81146.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.B10

Organism

Organism UniProt Comment Textmining
Homo sapiens O43184
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-

Source Tissue

Source Tissue Comment Organism Textmining
memory T-lymphocyte
-
 Homo sapiens
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naive T-cell
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 Homo sapiens
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regulatory T-lymphocyte
-
 Homo sapiens
-
Th17 cell interleukin-17-secreting T cell Homo sapiens
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Synonyms

Synonyms Comment Organism
ADAM12
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of ADAM12 is enriched in interleukin-17 secreting T cells up

General Information

General Information Comment Organism
malfunction enzyme knockdown greatly enhances interleukin-17-secreting cell differentiation, more potently then inhibiting transforming growth factor beta signals Homo sapiens
physiological function the enzyme plays a regulatory role in Th17 cell differentiation or function Homo sapiens